Literature DB >> 25827347

Neural stem cell-mediated delivery of oncolytic adenovirus.

Julius W Kim1, J Robert Kane1, Jacob S Young1, Alan L Chang1, Deepak Kanojia1, Shuo Qian1, Drew A Spencer1, Atique U Ahmed1, Maciej S Lesniak1.   

Abstract

The use of stem cells (SCs) as carriers for therapeutic agents has now progressed to early clinical trials. These clinical trials exploring SC-mediated delivery of oncolytic adenoviruses will commence in the near future, hopefully yielding meritorious results that can provoke further scientific inquiry. Preclinical animal studies have demonstrated that SCs can be successfully loaded with conditionally-replicative adenoviruses and delivered to the tumor, whereupon they may evoke pronounced therapeutic efficacy. In this protocol, we describe the maintenance of SCs, provide an analysis of optimal adenoviral titers for SC loading, and evaluate the optimized viral loading on SCs.
Copyright © 2015 John Wiley & Sons, Inc.

Entities:  

Keywords:  cancer; gene therapy; mesenchymal stem cell; neural stem cell; oncolytic adenovirus

Mesh：

Year:  2015        PMID： 25827347      PMCID： PMC4403729          DOI： 10.1002/0471142905.hg1311s85

Source DB:  PubMed          Journal:  Curr Protoc Hum Genet        ISSN： 1934-8258


  15 in total

Review 1.  Maintaining and loading neural stem cells for delivery of oncolytic adenovirus to brain tumors.

Authors:  Atique U Ahmed; Ilya V Ulasov; Ronald W Mercer; Maciej S Lesniak
Journal:  Methods Mol Biol       Date:  2012

2.  Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma.

Authors:  Atique U Ahmed; Bart Thaci; Nikita G Alexiades; Yu Han; Shuo Qian; Feifei Liu; Irina V Balyasnikova; Ilya Y Ulasov; Karen S Aboody; Maciej S Lesniak
Journal:  Mol Ther       Date:  2011-05-31       Impact factor: 11.454

3.  A preclinical evaluation of neural stem cell-based cell carrier for targeted antiglioma oncolytic virotherapy.

Authors:  Atique U Ahmed; Bart Thaci; Alex L Tobias; Brenda Auffinger; Lingjiao Zhang; Yu Cheng; Chung Kwon Kim; Catherine Yunis; Yu Han; Nikita G Alexiades; Xiaobing Fan; Karen S Aboody; Maciej S Lesniak
Journal:  J Natl Cancer Inst       Date:  2013-07-03       Impact factor: 13.506

4.  A specific subpopulation of mesenchymal stromal cell carriers overrides melanoma resistance to an oncolytic adenovirus.

Authors:  Marcela F Bolontrade; Leonardo Sganga; Eduardo Piaggio; Diego L Viale; Miguel A Sorrentino; Aníbal Robinson; Gustavo Sevlever; Mariana G García; Guillermo Mazzolini; Osvaldo L Podhajcer
Journal:  Stem Cells Dev       Date:  2012-05-14       Impact factor: 3.272

5.  Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.

Authors:  K S Aboody; A Brown; N G Rainov; K A Bower; S Liu; W Yang; J E Small; U Herrlinger; V Ourednik; P M Black; X O Breakefield; E Y Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

6.  Fiber-knob modifications enhance adenoviral tropism and gene transfer in malignant glioma.

Authors:  Sophy Zheng; Ilya V Ulasov; Yu Han; Matthew A Tyler; Zeng B Zhu; Maciej S Lesniak
Journal:  J Gene Med       Date:  2007-03       Impact factor: 4.565

Review 7.  Innate immunity to adenovirus.

Authors:  Rodinde Hendrickx; Nicole Stichling; Jorien Koelen; Lukasz Kuryk; Agnieszka Lipiec; Urs F Greber
Journal:  Hum Gene Ther       Date:  2014-04-08       Impact factor: 5.695

8.  The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma.

Authors:  Alex L Tobias; Bart Thaci; Brenda Auffinger; Esther Rincón; Irina V Balyasnikova; Chung Kwon Kim; Yu Han; Lingjiao Zhang; Karen S Aboody; Atique U Ahmed; Maciej S Lesniak
Journal:  Stem Cells Transl Med       Date:  2013-08-07       Impact factor: 6.940

9.  Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model.

Authors:  B Thaci; A U Ahmed; I V Ulasov; A L Tobias; Y Han; K S Aboody; M S Lesniak
Journal:  Cancer Gene Ther       Date:  2012-05-04       Impact factor: 5.987

10.  An adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer.

Authors:  Julius W Kim; Joel N Glasgow; Masaharu Nakayama; Ferhat Ak; Hideyo Ugai; David T Curiel
Journal:  PLoS One       Date:  2013-02-01       Impact factor: 3.240
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  2 in total

Review 1.  Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy: Translational Opportunity and Open Questions.

Authors:  Janice Kim; Robert R Hall; Maciej S Lesniak; Atique U Ahmed
Journal:  Viruses       Date:  2015-11-27       Impact factor: 5.048

2.  Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters.

Authors:  Julius Woongki Kim; Brenda Auffinger; Drew A Spencer; Jason Miska; Alan L Chang; Joshua Robert Kane; Jacob S Young; Deepak Kanojia; Jian Qiao; Jill F Mann; Lingjiao Zhang; Meijing Wu; Atique U Ahmed; Karen S Aboody; Theresa V Strong; Charles D Hébert; Maciej S Lesniak
Journal:  J Transl Med       Date:  2016-05-16       Impact factor: 5.531
  2 in total

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