Literature DB >> 2582695

Adolescent cocaine abuse. Addictive potential, behavioral and psychiatric effects.

T W Estroff1, R H Schwartz, N G Hoffmann.   

Abstract

Four hundred seventy-nine drug abusing adolescent patients enrolled in seven Straight, Inc. Adolescent Drug-Abuse Treatment Programs in five geographic regions across the United States were studied to determine the severity and patterns of cocaine abuse. Of these, 341 admitted to cocaine use and became part of this survey. Cocaine use was categorized as heavy, intermediate, or light. Areas examined were the addictive spectrum, psychosocial dysfunction, and psychiatric symptoms. Intermediate and heavy users of cocaine abused significantly less marijuana and inhalants than light cocaine abusers. Heavy and intermediate users were more likely to use cocaine intravenously and to use crack. They developed tachyphylaxis more frequently, progressed to weekly use in less than 3 months more frequently, and became preoccupied with obtaining and using cocaine significantly more frequently. They used more sedative hypnotics to calm themselves and engaged in more criminal behavior, such as stealing from parents and stores and passing bad checks. They had more arrests for possession of drugs, stole more cars, sold more drugs, and were more likely to trade sexual favors to obtain the drug. Heavy and intermediate users were significantly more psychiatrically disturbed than light users, becoming more suspicious, nervous, aggressive, and demonstrating increased symptoms of fatigue, sleeplessness, decreased appetite, and increasing cocaine dysphoria. All of these symptoms could be mistaken for psychiatric disorders. This study suggests that cocaine is as addictive in adolescents as in adults; possibly more so. It also causes psychosocial dysfunction and psychiatric symptoms. Further research into cocaine addiction among adolescents is indicated.

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Year:  1989        PMID: 2582695     DOI: 10.1177/000992288902801201

Source DB:  PubMed          Journal:  Clin Pediatr (Phila)        ISSN: 0009-9228            Impact factor:   1.168


  23 in total

Review 1.  Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability.

Authors:  R Andrew Chambers; Jane R Taylor; Marc N Potenza
Journal:  Am J Psychiatry       Date:  2003-06       Impact factor: 18.112

2.  Escalation of methamphetamine self-administration in adolescent and adult rats.

Authors:  Justin J Anker; Thomas R Baron; Natalie E Zlebnik; Marilyn E Carroll
Journal:  Drug Alcohol Depend       Date:  2012-02-02       Impact factor: 4.492

Review 3.  Differential effects of psychoactive drugs in adolescents and adults.

Authors:  Sari Izenwasser
Journal:  Crit Rev Neurobiol       Date:  2005

4.  An investigation of the behavioral actions of ethanol across adolescence in mice.

Authors:  Kathryn Hefner; Andrew Holmes
Journal:  Psychopharmacology (Berl)       Date:  2007-01-06       Impact factor: 4.530

5.  Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.

Authors:  Jennifer L Perry; Marissa M Anderson; Sarah E Nelson; Marilyn E Carroll
Journal:  Physiol Behav       Date:  2007-02-12

6.  Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats.

Authors:  David A White; Clifford C Michaels; Stephen G Holtzman
Journal:  Pharmacol Biochem Behav       Date:  2007-12-15       Impact factor: 3.533

7.  Evaluation of a pharmacokinetic hypothesis for reduced locomotor stimulation from methamphetamine and cocaine in adolescent versus adult male C57BL/6J mice.

Authors:  Jonathan A Zombeck; Tripta Gupta; Justin S Rhodes
Journal:  Psychopharmacology (Berl)       Date:  2008-09-17       Impact factor: 4.530

8.  Differential effects of methamphetamine and cocaine on conditioned place preference and locomotor activity in adult and adolescent male rats.

Authors:  Elena Zakharova; Giorgia Leoni; Ilona Kichko; Sari Izenwasser
Journal:  Behav Brain Res       Date:  2008-10-18       Impact factor: 3.332

Review 9.  The emergence of gonadal hormone influences on dopaminergic function during puberty.

Authors:  Cynthia Kuhn; Misha Johnson; Alex Thomae; Brooke Luo; Sidney A Simon; Guiying Zhou; Q David Walker
Journal:  Horm Behav       Date:  2009-11-10       Impact factor: 3.587

10.  Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats.

Authors:  Justin J Anker; Marilyn E Carroll
Journal:  Psychopharmacology (Berl)       Date:  2009-12-02       Impact factor: 4.530

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