Literature DB >> 25826784

Simple "on-demand" production of bioactive natural products.

Edna Bode1, Alexander O Brachmann, Carsten Kegler, Rukayye Simsek, Christina Dauth, Qiuqin Zhou, Marcel Kaiser, Petra Klemmt, Helge B Bode.   

Abstract

Exchange of the native promoter to the arabinose-inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the "on-demand" production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel "mevalagmapeptides" and the highly toxic xenorhabdins were identified by this approach.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  biosynthesis; natural products; overproduction; promoter-exchange approach; “silent” gene cluster

Mesh：

Substances：

Year:  2015        PMID： 25826784     DOI： 10.1002/cbic.201500094

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  21 in total

Review 1.  Natural products from Photorhabdus and Xenorhabdus: mechanisms and impacts.

Authors:  Harun Cimen; Mustapha Touray; Sebnem Hazal Gulsen; Selcuk Hazir
Journal:  Appl Microbiol Biotechnol       Date:  2022-06-20       Impact factor: 4.813

2.  Antiprotozoal activity of different Xenorhabdus and Photorhabdus bacterial secondary metabolites and identification of bioactive compounds using the easyPACId approach.

Authors:  Sebnem Hazal Gulsen; Evren Tileklioglu; Edna Bode; Harun Cimen; Hatice Ertabaklar; Derya Ulug; Sema Ertug; Sebastian L Wenski; Mustapha Touray; Canan Hazir; Duygu Kaya Bilecenoglu; Ibrahim Yildiz; Helge B Bode; Selcuk Hazir
Journal:  Sci Rep       Date:  2022-06-24       Impact factor: 4.996

3.  Antifungal activity of different Xenorhabdus and Photorhabdus species against various fungal phytopathogens and identification of the antifungal compounds from X. szentirmaii.

Authors:  Harun Cimen; Mustapha Touray; Sebnem Hazal Gulsen; Omer Erincik; Sebastian L Wenski; Helge B Bode; David Shapiro-Ilan; Selcuk Hazir
Journal:  Appl Microbiol Biotechnol       Date:  2021-07-12       Impact factor: 4.813

4.  CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria.

Authors:  Gaoyan Wang; Zhiying Zhao; Jing Ke; Yvonne Engel; Yi-Ming Shi; David Robinson; Kerem Bingol; Zheyun Zhang; Benjamin Bowen; Katherine Louie; Bing Wang; Robert Evans; Yu Miyamoto; Kelly Cheng; Suzanne Kosina; Markus De Raad; Leslie Silva; Alicia Luhrs; Andrea Lubbe; David W Hoyt; Charles Francavilla; Hiroshi Otani; Samuel Deutsch; Nancy M Washton; Edward M Rubin; Nigel J Mouncey; Axel Visel; Trent Northen; Jan-Fang Cheng; Helge B Bode; Yasuo Yoshikuni
Journal:  Nat Microbiol       Date:  2019-10-14       Impact factor: 17.745

Review 5.  Recent highlights in biosynthesis research using stable isotopes.

Authors:  Jan Rinkel; Jeroen S Dickschat
Journal:  Beilstein J Org Chem       Date:  2015-12-09       Impact factor: 2.883

6.  Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle.

Authors:  Nicholas J Tobias; Bagdevi Mishra; Deepak K Gupta; Rahul Sharma; Marco Thines; Timothy P Stinear; Helge B Bode
Journal:  BMC Genomics       Date:  2016-08-03       Impact factor: 3.969

Review 7.  Predominately Uncultured Microbes as Sources of Bioactive Agents.

Authors:  David J Newman
Journal:  Front Microbiol       Date:  2016-11-18       Impact factor: 5.640

8.  Screening of the Antimicrobial Activity against Drug Resistant Bacteria of Photorhabdus and Xenorhabdus Associated with Entomopathogenic Nematodes from Mae Wong National Park, Thailand.

Authors:  Paramaporn Muangpat; Temsiri Yooyangket; Chamaiporn Fukruksa; Manawat Suwannaroj; Thatcha Yimthin; Sutthirat Sitthisak; Narisara Chantratita; Apichat Vitta; Nicholas J Tobias; Helge B Bode; Aunchalee Thanwisai
Journal:  Front Microbiol       Date:  2017-06-28       Impact factor: 5.640

9.  Post-translational formation of strained cyclophanes in bacteria.

Authors:  Thi Quynh Ngoc Nguyen; Yi Wei Tooh; Ryosuke Sugiyama; Thi Phuong Diep Nguyen; Mugilarasi Purushothaman; Li Chuan Leow; Karyna Hanif; Rubin How Sheng Yong; Irene Agatha; Fernaldo R Winnerdy; Muriel Gugger; Anh Tuân Phan; Brandon I Morinaka
Journal:  Nat Chem       Date:  2020-08-17       Impact factor: 24.427

10.  Relative potency of a novel acaricidal compound from Xenorhabdus, a bacterial genus mutualistically associated with entomopathogenic nematodes.

Authors:  Gamze Incedayi; Harun Cimen; Derya Ulug; Mustapha Touray; Edna Bode; Helge B Bode; Esra Orenlili Yaylagul; Selcuk Hazir; Ibrahim Cakmak
Journal:  Sci Rep       Date:  2021-05-27       Impact factor: 4.379
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