Literature DB >> 25825622

A numerical study on the dynamics of droplet formation in a microfluidic double T-junction.

Ich-Long Ngo1, Trung-Dung Dang2, Chan Byon1, Sang Woo Joo1.   

Abstract

In this study, droplet formations in microfluidic double T-junctions (MFDTD) are investigated based on a two-dimensional numerical model with volume of fluid method. Parametric ranges for generating alternating droplet formation (ADF) are identified. A physical background responsible for the ADF is suggested by analyzing the dynamical stability of flow system. Since the phase discrepancy between dispersed flows is mainly caused by non-symmetrical breaking of merging droplet, merging regime becomes the alternating regime at appropriate conditions. In addition, the effects of channel geometries on droplet formation are studied in terms of relative channel width. The predicted results show that the ADF region is shifted toward lower capillary numbers when channel width ratio is less than unity. The alternating droplet size increases with the increase of channel width ratio. When this ratio reaches unity, alternating droplets can be formed at very high water fraction (wf = 0.8). The droplet formation in MFDTD depends significantly on the viscosity ratio, and the droplet size in ADF decreases with the increase of the viscosity ratio. The understanding of underlying physics of the ADF phenomenon is useful for many applications, including nanoparticle synthesis with different concentrations, hydrogel bead generation, and cell transplantation in biomedical therapy.

Entities:  

Year:  2015        PMID: 25825622      PMCID: PMC4376751          DOI: 10.1063/1.4916228

Source DB:  PubMed          Journal:  Biomicrofluidics        ISSN: 1932-1058            Impact factor:   2.800


  20 in total

1.  Dynamic pattern formation in a vesicle-generating microfluidic device.

Authors:  T Thorsen; R W Roberts; F H Arnold; S R Quake
Journal:  Phys Rev Lett       Date:  2001-04-30       Impact factor: 9.161

2.  Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays.

Authors:  Bo Zheng; Joshua D Tice; Rustem F Ismagilov
Journal:  Anal Chem       Date:  2004-09-01       Impact factor: 6.986

3.  Flows around confined bubbles and their importance in triggering pinch-off.

Authors:  Volkert van Steijn; Chris R Kleijn; Michiel T Kreutzer
Journal:  Phys Rev Lett       Date:  2009-11-19       Impact factor: 9.161

4.  Predictive model for the size of bubbles and droplets created in microfluidic T-junctions.

Authors:  Volkert van Steijn; Chris R Kleijn; Michiel T Kreutzer
Journal:  Lab Chip       Date:  2010-07-09       Impact factor: 6.799

5.  Modeling of droplet breakup in a microfluidic T-shaped junction with a phase-field model.

Authors:  Mario De Menech
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2006-03-30

6.  Janus and ternary particles generated by microfluidic synthesis: design, synthesis, and self-assembly.

Authors:  Zhihong Nie; Wei Li; Minseok Seo; Shengqing Xu; Eugenia Kumacheva
Journal:  J Am Chem Soc       Date:  2006-07-26       Impact factor: 15.419

7.  Surface-induced droplet fusion in microfluidic devices.

Authors:  Luis M Fidalgo; Chris Abell; Wilhelm T S Huck
Journal:  Lab Chip       Date:  2007-07-10       Impact factor: 6.799

Review 8.  Droplet microfluidics.

Authors:  Shia-Yen Teh; Robert Lin; Lung-Hsin Hung; Abraham P Lee
Journal:  Lab Chip       Date:  2008-01-11       Impact factor: 6.799

9.  Lattice Boltzmann simulations of bubble formation in a microfluidic T-junction.

Authors:  Luz Amaya-Bower; Taehun Lee
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2011-06-28       Impact factor: 4.226

10.  Preparation of tadpole-shaped calcium alginate microparticles with sphericity control.

Authors:  T D Dang; S W Joo
Journal:  Colloids Surf B Biointerfaces       Date:  2012-09-17       Impact factor: 5.268

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