I Sawazaki-Calone1,2, Alca Rangel1, A G Bueno3, C F Morais4, H M Nagai5, R P Kunz6, R L Souza1, L Rutkauskis1, T Salo2,7,8, A Almangush7,8, R D Coletta2. 1. Oral Pathology and Oral Medicine, Dentistry School, Western Paraná State University, Cascavel, Brazil. 2. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. 3. ANATOM Anatomic Pathology Laboratory, Cascavel, Brazil. 4. APC Anatomic Pathology Laboratory, Cascavel, Brazil. 5. UOPECCAN Cancer Hospital, Cascavel, Brazil. 6. Oncology Center of Cascavel (CEONC), Cascavel, Brazil. 7. Department of Diagnostics and Oral Medicine, Institute of Dentistry and Oulu University Hospital, University of Oulu, Oulu, Finland. 8. Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Abstract
OBJECTIVE: This study evaluated the association of four histopathological grading systems (WHO grading system, malignancy grading of the deep invasive margins (MG), histological risk (HR) model, and tumor budding and depth of invasion (BD) model) with clinicopathological parameters and outcome of 113 oral squamous cell carcinomas to identify their roles in prognosis. METHODS: Demographic and clinical features were obtained from patients' records. Sections from all paraffin-embedded blocks were evaluated according to the four grading systems. Demographic and clinical associations were analyzed using chi-square test, and correlations between the grading systems were established with the Spearman's rank correlation test. Survival curves were performed with Kaplan-Meier method, and multivariate analysis based on Cox proportional hazard model was calculated. RESULTS: Significant associations with survival were observed for WHO grading system and BD model in the univariate analysis, but only the BD model was significantly associated with disease outcome as an independent prognostic marker. Age, tumor size, and presence of regional metastasis were also independent markers of reduced survival. CONCLUSION: A significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool.
OBJECTIVE: This study evaluated the association of four histopathological grading systems (WHO grading system, malignancy grading of the deep invasive margins (MG), histological risk (HR) model, and tumor budding and depth of invasion (BD) model) with clinicopathological parameters and outcome of 113 oral squamous cell carcinomas to identify their roles in prognosis. METHODS: Demographic and clinical features were obtained from patients' records. Sections from all paraffin-embedded blocks were evaluated according to the four grading systems. Demographic and clinical associations were analyzed using chi-square test, and correlations between the grading systems were established with the Spearman's rank correlation test. Survival curves were performed with Kaplan-Meier method, and multivariate analysis based on Cox proportional hazard model was calculated. RESULTS: Significant associations with survival were observed for WHO grading system and BD model in the univariate analysis, but only the BD model was significantly associated with disease outcome as an independent prognostic marker. Age, tumor size, and presence of regional metastasis were also independent markers of reduced survival. CONCLUSION: A significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool.
Authors: Alhadi Almangush; Ilmo Leivo; Maria Siponen; Elias Sundquist; Rayan Mroueh; Antti A Mäkitie; Ylermi Soini; Caj Haglund; Pentti Nieminen; Tuula Salo Journal: Virchows Arch Date: 2017-08-02 Impact factor: 4.064
Authors: Elizabete Bagordakis; Iris Sawazaki-Calone; Carolina Carneiro Soares Macedo; Carolina M Carnielli; Carine Ervolino de Oliveira; Priscila Campioni Rodrigues; Ana Lucia C A Rangel; Jean Nunes Dos Santos; Juha Risteli; Edgard Graner; Tuula Salo; Adriana Franco Paes Leme; Ricardo D Coletta Journal: Tumour Biol Date: 2016-01-13
Authors: Priscila Campioni Rodrigues; Iris Sawazaki-Calone; Carine Ervolino de Oliveira; Carolina Carneiro Soares Macedo; Mauricio Rocha Dourado; Nilva K Cervigne; Marcia Costa Miguel; Andreia Ferreira do Carmo; Daniel W Lambert; Edgard Graner; Sabrina Daniela da Silva; Moulay A Alaoui-Jamali; Adriana Franco Paes Leme; Tuula A Salo; Ricardo D Coletta Journal: Oncotarget Date: 2017-08-19
Authors: Alhadi Almangush; Matti Pirinen; Ilkka Heikkinen; Antti A Mäkitie; Tuula Salo; Ilmo Leivo Journal: Br J Cancer Date: 2017-11-30 Impact factor: 7.640
Authors: Leonard Leifels; Sandra Purz; Patrick Stumpp; Stefan Schob; Hans Jonas Meyer; Thomas Kahn; Osama Sabri; Alexey Surov Journal: Contrast Media Mol Imaging Date: 2017-10-19 Impact factor: 3.161