Jun Kakogawa1, Takafumi Nako2, Kazuhiro Kawamura2, Shin Nakamura2, Ayako Mochiduki3, Naohiro Kanayama3, Mamoru Tanaka2. 1. Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan. Electronic address: jkakogawa@marianna-u.ac.jp. 2. Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan. 3. Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Abstract
BACKGROUND: Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival. CASE: We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section. SUMMARY AND CONCLUSIONS: Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.
BACKGROUND:Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival. CASE: We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section. SUMMARY AND CONCLUSIONS: Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.