Kimberly Geoghegan1, Jeffrey W Bode1. 1. Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir Prelog Weg 3, CH-8093 Zürich, Switzerland.
Abstract
The precise placement of C-substituents on bicyclic and spirocyclic N-heterocycles is readily achieved by the combination of aldehydes and new SnAP reagents. The substituted SnAP reagents are readily prepared from simple starting materials and couple with a variety of aromatic and heteroaromatic aldehydes at room temperature under operationally simple conditions to deliver substituted morpholine and piperazine products.
The precise placement of C-substituents on bicyclic and spirocyclic N-heterocycles is readily achieved by the combination of n class="Chemical">aldehydes and new SnAP reagents. The substituted SnAP reagents are readily prepared from simple starting materials and couple with a variety of aromatic and heteroaromatic aldehydes at room temperature under operationally simple conditions to deliver substituted morpholine and piperazine products.
Authors: Darren W Engers; Sean R Bollinger; Andrew S Felts; Anish K Vadukoot; Charles H Williams; Anna L Blobaum; Craig W Lindsley; Charles C Hong; Corey R Hopkins Journal: Bioorg Med Chem Lett Date: 2020-07-17 Impact factor: 2.823
Authors: Thomas A King; Hannah L Stewart; Kim T Mortensen; Andrew J P North; Hannah F Sore; David R Spring Journal: European J Org Chem Date: 2019-07-29