| Literature DB >> 25822007 |
María Eva González-Trujano1, Francisco Pellicer, Pedro Mena, Diego A Moreno, Cristina García-Viguera.
Abstract
Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.Entities:
Keywords: Anti-inflammatory; anthocyanin; antinociception; ellagitannin; formalin test; gastroprotection
Mesh：
Substances：
Year: 2015 PMID： 25822007 DOI： 10.3109/09637486.2015.1024208
Source DB: PubMed Journal: Int J Food Sci Nutr ISSN： 0963-7486 Impact factor: 3.833