Carmen S Arriola1, Evan J Anderson2, Joan Baumbach3, Nancy Bennett4, Susan Bohm5, Mary Hill6, Mary Lou Lindegren7, Krista Lung8, James Meek9, Elizabeth Mermel10, Lisa Miller11, Maya L Monroe12, Craig Morin13, Oluwakemi Oni14, Arthur Reingold15, William Schaffner7, Ann Thomas16, Shelley M Zansky17, Lyn Finelli18, Sandra S Chaves18. 1. Epidemic Intelligence Service Program Influenza Division, Centers for Disease Control and Prevention. 2. Department of Medicine, Emory University School of Medicine Atlanta Veterans Affairs Medical Center, Georgia. 3. New Mexico Department of Health, Santa Fe. 4. Department of Medicine, University of Rochester School of Medicine and Dentistry. 5. Michigan Department of Community Health, Lansing. 6. Salt Lake County Health Department, Utah. 7. Vanderbilt University School of Medicine, Nashville, Tennessee. 8. Ohio Department of Health, Columbus. 9. Connecticut Emerging Infections Program, Yale School of Public Health, New Haven. 10. Rhode Island Department of Health, Providence. 11. Colorado Department of Public Health and Environment, Denver. 12. Maryland Department of Health and Mental Hygiene, Baltimore. 13. Minnesota Department of Health, St. Paul. 14. Iowa Department of Public Health, Des Moines. 15. California Emerging Infections Program, Oakland. 16. Oregon Public Health Division, Portland. 17. Emerging Infections Program, New York State Department of Health, Albany, New York. 18. Influenza Division, Centers for Disease Control and Prevention.
Abstract
BACKGROUND: Some studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza severity in adults aged ≥50 years who were hospitalized with laboratory-confirmed influenza. METHODS: We analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012-2013 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models, and propensity score matching (PSM). RESULTS: Overall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50-64 years (but not other age groups) who were vaccinated against influenza had a shorter length of ICU stay than those who were unvaccinated (hazard ratio for discharge, 1.84; 95% confidence interval, 1.12-3.01). CONCLUSIONS: Our findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
BACKGROUND: Some studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza severity in adults aged ≥50 years who were hospitalized with laboratory-confirmed influenza. METHODS: We analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012-2013 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models, and propensity score matching (PSM). RESULTS: Overall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50-64 years (but not other age groups) who were vaccinated against influenza had a shorter length of ICU stay than those who were unvaccinated (hazard ratio for discharge, 1.84; 95% confidence interval, 1.12-3.01). CONCLUSIONS: Our findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Entities:
Keywords:
adults; influenza; influenza vaccine; severe illness
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