BACKGROUND: We studied the correlation between prenatal diagnosis and postmortem investigations in pregnancies terminated for renal malformations. METHODS: Over a 5-year period, 77 cases of termination of pregnancy (TOP) for renal malformations were reviewed. Chromosomal anomalies (n = 9) and cases without conventional or virtual autopsy were excluded (n = 15). In 53 cases, prenatal ultrasound diagnosis and conventional autopsy findings were compared. In addition, we compared the accuracy of conventional and virtual autopsy findings in 17 cases. RESULTS: Full agreement was observed in 60.4% (32/53) of cases. In 26.4% (14/53) of the cases, the presence of additional malformations did not alter the final diagnosis. However, in 11.3% (6/53) the final diagnosis was adjusted because of major additional findings. One case showed a total disagreement. Conventional and virtual autopsy were in full agreement in 52.9% (9/17). Postmortem magnetic resonance imaging (MRI) description and detection of malformations was less complete and failed to correctly diagnose 5/17 cases (29.4%). In 17.6% (3/17) of the cases, postmortem MRI revealed malformations not confirmed by conventional autopsy. CONCLUSIONS: A high correlation between prenatal ultrasound and postmortem investigations was observed. Conventional autopsy remains the gold standard to reveal additional major and minor malformations, leading to a correct final diagnosis. The added value of virtual necropsy for renal pathology was limited.
BACKGROUND: We studied the correlation between prenatal diagnosis and postmortem investigations in pregnancies terminated for renal malformations. METHODS: Over a 5-year period, 77 cases of termination of pregnancy (TOP) for renal malformations were reviewed. Chromosomal anomalies (n = 9) and cases without conventional or virtual autopsy were excluded (n = 15). In 53 cases, prenatal ultrasound diagnosis and conventional autopsy findings were compared. In addition, we compared the accuracy of conventional and virtual autopsy findings in 17 cases. RESULTS: Full agreement was observed in 60.4% (32/53) of cases. In 26.4% (14/53) of the cases, the presence of additional malformations did not alter the final diagnosis. However, in 11.3% (6/53) the final diagnosis was adjusted because of major additional findings. One case showed a total disagreement. Conventional and virtual autopsy were in full agreement in 52.9% (9/17). Postmortem magnetic resonance imaging (MRI) description and detection of malformations was less complete and failed to correctly diagnose 5/17 cases (29.4%). In 17.6% (3/17) of the cases, postmortem MRI revealed malformations not confirmed by conventional autopsy. CONCLUSIONS: A high correlation between prenatal ultrasound and postmortem investigations was observed. Conventional autopsy remains the gold standard to reveal additional major and minor malformations, leading to a correct final diagnosis. The added value of virtual necropsy for renal pathology was limited.
Authors: Ibrahim A Abdelazim; Khaled M Abdelrazak; Ahmed R M Ramy; Ahmed M Mounib Journal: Aust N Z J Obstet Gynaecol Date: 2010-06 Impact factor: 2.100
Authors: Sudhin Thayyil; Neil J Sebire; Lyn S Chitty; Angie Wade; Oystein Olsen; Roxana S Gunny; Amaka Offiah; Dawn E Saunders; Catherine M Owens; W K Kling Chong; Nicola J Robertson; Andrew M Taylor Journal: BMC Pediatr Date: 2011-12-22 Impact factor: 2.125
Authors: Sudhin Thayyil; Neil J Sebire; Lyn S Chitty; Angie Wade; Wk Chong; Oystein Olsen; Roxana S Gunny; Amaka C Offiah; Catherine M Owens; Dawn E Saunders; Rosemary J Scott; Rod Jones; Wendy Norman; Shea Addison; Alan Bainbridge; Ernest B Cady; Enrico De Vita; Nicola J Robertson; Andrew M Taylor Journal: Lancet Date: 2013-05-16 Impact factor: 79.321