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Literature DB >> 2582093

Calcium channel antagonism by pizotifen.

Abstract

Pizotifen is a clinically effective anti-migraine agent with potent anti-serotonin and anti-histamine properties. Pizotifen is equipotent in blocking contractions of the canine basilar artery induced by serotonin, norepinephrine or calcium chloride. As a result, the primary action of pizotifen in the canine basilar artery system appears to be calcium channel blockade and not selective antagonism of serotonin or norepinephrine. Calcium channel blocking ability may be related to the clinical efficacy of pizotifen in the treatment of migraine.

Entities: Chemical Disease Species

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Year: 1985 PMID： 2582093 PMCID： PMC1028307 DOI： 10.1136/jnnp.48.4.381

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

11 in total

1. Cerebral arterial spasm. Part 4: in vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery.

Authors: G S Allen; C J Gross; L M Henderson; S N Chou
Journal: J Neurosurg Date: 1976-05 Impact factor: 5.115

2. Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine.

Authors: J E Hardebo; L Edvinsson; C Owman; N A Svendgaard
Journal: Neurology Date: 1978-01 Impact factor: 9.910

Review 3. Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine.

Authors: W K Amery
Journal: Headache Date: 1983-03 Impact factor: 5.887

4. Nimodipine, a new calcium antagonist, in the prophylactic treatment of migraine.

Authors: H J Gelmers
Journal: Headache Date: 1983-05 Impact factor: 5.887

5. Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches.

Authors: J S Meyer; J Hardenberg
Journal: Headache Date: 1983-11 Impact factor: 5.887

6. Flunarizine, a calcium channel blocker, in the prophylactic treatment of migraine.

Authors: S Diamond; H Schenbaum
Journal: Headache Date: 1983-01 Impact factor: 5.887

Review 7. Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.

Authors: T M Speight; G S Avery
Journal: Drugs Date: 1972 Impact factor: 9.546

8. Serotoninergic receptors in brain tissue: properties and identification of various 3H-ligand binding sites in vitro.

Authors: J E Leysen
Journal: J Physiol (Paris) Date: 1981

9. The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea-pig taenia coli.

Authors: D A Lowe; E K Matthews; B P Richardson
Journal: Br J Pharmacol Date: 1981-11 Impact factor: 8.739

10. Verapamil prophylaxis of migraine. A double-blind, placebo-controlled study.

Authors: G D Solomon; J G Steel; L J Spaccavento
Journal: JAMA Date: 1983-11-11 Impact factor: 56.272

1 in total

Review 1. Childhood functional abdominal pain: mechanisms and management.

Authors: Judith Korterink; Niranga Manjuri Devanarayana; Shaman Rajindrajith; Arine Vlieger; Marc A Benninga
Journal: Nat Rev Gastroenterol Hepatol Date: 2015-02-10 Impact factor: 46.802

1 in total