| Literature DB >> 25820181 |
Nicole Heussinger1, Evangelos Kontopantelis2, Janina Gburek-Augustat3, Andreas Jenke4, Gesa Vollrath5, Rudolf Korinthenberg6, Peter Hofstetter7, Sascha Meyer8, Isabel Brecht9, Barbara Kornek10, Peter Herkenrath11, Mareike Schimmel12, Kirsten Wenner13, Martin Häusler14, Soeren Lutz15, Michael Karenfort16, Astrid Blaschek17, Martin Smitka18, Stephanie Karch19, Martin Piepkorn20, Kevin Rostasy21, Thomas Lücke22, Peter Weber23, Regina Trollmann24, Jörg Klepper1, Martin Häussler25, Regina Hofmann26, Robert Weissert27, Andreas Merkenschlager28, Mathias Buttmann9.
Abstract
We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR] = 5.94, 95% confidence interval [CI] = 3.39-10.39, p < 0.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p < 0.001), and age (HR = 1.08 per year of age, 95% CI = 1.02-1.13, p = 0.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI = 12.26-58.74, p < 0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON.Entities:
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Year: 2015 PMID： 25820181 DOI： 10.1002/ana.24409
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422