Helmi Ben Saad1, Ikram Ben Hassen2, Ines Ghannouchi3, Imed Latiri4, Sonia Rouatbi3, Pierre Escourrou5, Halima Ben Salem2, Mohamed Benzarti2, Ahmed Abdelghani6. 1. Research Laboratory LR14ES05: Interaction of the Cardiorespiratory System, Faculty of Medicine of Sousse, Sousse, Tunisia; Laboratory of Physiology, Faculty of Medicine, University of Sousse, Tunisia; Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia. Electronic address: helmi.bensaad@rns.tn. 2. Pulmonary Department, Farhat HACHED Hospital, Sousse, Tunisia. 3. Laboratory of Physiology, Faculty of Medicine, University of Sousse, Tunisia; Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia. 4. Department of Physiology and Functional Explorations, Farhat HACHED Hospital, Sousse, Tunisia. 5. Laboratory of Functional Exploration, Hospital Antoine Béclère, Clamart, France. 6. Research Laboratory LR14ES05: Interaction of the Cardiorespiratory System, Faculty of Medicine of Sousse, Sousse, Tunisia; Pulmonary Department, Farhat HACHED Hospital, Sousse, Tunisia.
Abstract
INTRODUCTION: Few studies have evaluated the functional capacity of severe OSAHS. AIMS: To assess their functional capacity, identify their 6-min walking-distance (6MWD) influencing factors and compare their data with those of two control-groups. METHODS: Sixty (42 males) clinically consecutive stable patients with severe OSAHS under CPAP were included. Clinical, Epworth questionnaire, anthropometric, polysomnographic, plethysmographic and 6-min walk-test (6MWT) data were collected. Univariate and multivariate analyses were used to identify the 6MWD influencing factors. Data of a subgroup of severe OSAHS aged ≥40 Yrs (n = 49) were compared with those of non-obese (n = 174) and obese (n = 55) groups. RESULTS: The means ± SD of age and apnea-hypopnea-index were, respectively, 49 ± 10 Yr and 62 ± 18/h. The profile of OSAHS patients carrying the 6MWT, was as follows: at the end of the 6MWT, 31% and 25% had, respectively, a high dyspnea (>5/10, visual analogue scale) and a low heart-rate (<60% of-maximal-predicted), 13% had an abnormal 6MWD (<lower-limit-of-normal), 13% had an oxy-hemoglobin saturation (oxy-sat) fall> 5 points and 3% stopped the walk. The factors that significantly influenced the 6MWD, explaining 80% of its variability, are included in the following equation: 6MWD (m) = 29.66 × first-second-forced-expiratory-volume (L) - 4.19 × Body-mass-index (kg/m(2)) - 51.89 × arterial-hypertension (0. No; 1. Yes) + 263.53 × Height (m) + 2.63 × average oxy-sat during sleep (%) - 51.06 × Diuretic-use (0. No; 1. Yes) - 20.68 × Dyspnea (NYHA) (0. No; 1. Yes) - 38.09 × Anemia (0. No; 1. Yes) + 5.79 × Resting oxy-sat (%) - 586.25. Compared with non-obese and obese groups, the subgroup of OSAHS has a significantly lower 6MWD [100 ± 9%, 100 ± 8% and 83 ± 12%, respectively). CONCLUSION: Severe OSAHS may play a role in reducing the functional capacity.
INTRODUCTION: Few studies have evaluated the functional capacity of severe OSAHS. AIMS: To assess their functional capacity, identify their 6-min walking-distance (6MWD) influencing factors and compare their data with those of two control-groups. METHODS: Sixty (42 males) clinically consecutive stable patients with severe OSAHS under CPAP were included. Clinical, Epworth questionnaire, anthropometric, polysomnographic, plethysmographic and 6-min walk-test (6MWT) data were collected. Univariate and multivariate analyses were used to identify the 6MWD influencing factors. Data of a subgroup of severe OSAHS aged ≥40 Yrs (n = 49) were compared with those of non-obese (n = 174) and obese (n = 55) groups. RESULTS: The means ± SD of age and apnea-hypopnea-index were, respectively, 49 ± 10 Yr and 62 ± 18/h. The profile of OSAHS patients carrying the 6MWT, was as follows: at the end of the 6MWT, 31% and 25% had, respectively, a high dyspnea (>5/10, visual analogue scale) and a low heart-rate (<60% of-maximal-predicted), 13% had an abnormal 6MWD (<lower-limit-of-normal), 13% had an oxy-hemoglobin saturation (oxy-sat) fall> 5 points and 3% stopped the walk. The factors that significantly influenced the 6MWD, explaining 80% of its variability, are included in the following equation: 6MWD (m) = 29.66 × first-second-forced-expiratory-volume (L) - 4.19 × Body-mass-index (kg/m(2)) - 51.89 × arterial-hypertension (0. No; 1. Yes) + 263.53 × Height (m) + 2.63 × average oxy-sat during sleep (%) - 51.06 × Diuretic-use (0. No; 1. Yes) - 20.68 × Dyspnea (NYHA) (0. No; 1. Yes) - 38.09 × Anemia (0. No; 1. Yes) + 5.79 × Resting oxy-sat (%) - 586.25. Compared with non-obese and obese groups, the subgroup of OSAHS has a significantly lower 6MWD [100 ± 9%, 100 ± 8% and 83 ± 12%, respectively). CONCLUSION: Severe OSAHS may play a role in reducing the functional capacity.
Authors: Matheus Gustavo Silva Magalhães; Juliana Baptista Teixeira; Ana Maria Bezerra Santos; Danielle Cristina Silva Clímaco; Thayse Neves Santos Silva; Anna Myrna Jaguaribe de Lima Journal: J Bras Pneumol Date: 2020-04-22 Impact factor: 2.800