Literature DB >> 25820063

A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose.

Yoshimi Tsuda1, Christopher J Parkins2, Patrizia Caposio2, Friederike Feldmann3, Sara Botto2, Susan Ball4, Ilhem Messaoudi5, Luka Cicin-Sain6, Heinz Feldmann1, Michael A Jarvis7.   

Abstract

Ebola virus (Zaire ebolavirus; EBOV) is a highly lethal hemorrhagic disease virus that most recently was responsible for two independent 2014 outbreaks in multiple countries in Western Africa, and the Democratic Republic of the Congo, respectively. Herein, we show that a cytomegalovirus (CMV)-based vaccine provides durable protective immunity from Ebola virus following a single vaccine dose. This study has implications for human vaccination against ebolaviruses, as well as for development of a 'disseminating' vaccine to target these viruses in wild African great apes.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cytomegalovirus; Disseminating; Durable; Ebola; Ebolavirus; Great apes; Mouse; Protection; Vaccine

Mesh：

Substances：

Year:  2015        PMID： 25820063      PMCID： PMC4402448          DOI： 10.1016/j.vaccine.2015.03.029

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  33 in total

1.  Four distinct patterns of memory CD8 T cell responses to chronic murine cytomegalovirus infection.

Authors:  Michael W Munks; Kathy S Cho; Amelia K Pinto; Sophie Sierro; Paul Klenerman; Ann B Hill
Journal:  J Immunol       Date:  2006-07-01       Impact factor: 5.422

2.  Absence of frequent herpesvirus transmission in a nonhuman primate predator-prey system in the wild.

Authors:  Sripriya Murthy; Emmanuel Couacy-Hymann; Sonja Metzger; Kathrin Nowak; Helene De Nys; Christophe Boesch; Roman Wittig; Michael A Jarvis; Fabian H Leendertz; Bernhard Ehlers
Journal:  J Virol       Date:  2013-07-24       Impact factor: 5.103

3.  A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice.

Authors:  Rob Tierney; Toru Nakai; Christopher J Parkins; Patrizia Caposio; Neil F Fairweather; Dorothea Sesardic; Michael A Jarvis
Journal:  Vaccine       Date:  2012-03-10       Impact factor: 3.641

4.  Fruit bats as reservoirs of Ebola virus.

Authors:  Eric M Leroy; Brice Kumulungui; Xavier Pourrut; Pierre Rouquet; Alexandre Hassanin; Philippe Yaba; André Délicat; Janusz T Paweska; Jean-Paul Gonzalez; Robert Swanepoel
Journal:  Nature       Date:  2005-12-01       Impact factor: 49.962

5.  Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity.

Authors:  S B Boppana; L B Rivera; K B Fowler; M Mach; W J Britt
Journal:  N Engl J Med       Date:  2001-05-03       Impact factor: 91.245

6.  Ebola outbreak killed 5000 gorillas.

Authors:  Magdalena Bermejo; José Domingo Rodríguez-Teijeiro; Germán Illera; Alex Barroso; Carles Vilà; Peter D Walsh
Journal:  Science       Date:  2006-12-08       Impact factor: 47.728

7.  Multiple Ebola virus transmission events and rapid decline of central African wildlife.

Authors:  Eric M Leroy; Pierre Rouquet; Pierre Formenty; Sandrine Souquière; Annelisa Kilbourne; Jean-Marc Froment; Magdalena Bermejo; Sheilag Smit; William Karesh; Robert Swanepoel; Sherif R Zaki; Pierre E Rollin
Journal:  Science       Date:  2004-01-16       Impact factor: 47.728

Review 8.  The ecology of Ebola virus.

Authors:  Allison Groseth; Heinz Feldmann; James E Strong
Journal:  Trends Microbiol       Date:  2007-08-15       Impact factor: 17.079

9.  Cytomegalovirus reinfections in healthy seroimmune women.

Authors:  Shannon A Ross; Nitin Arora; Zdenek Novak; Karen B Fowler; William J Britt; Suresh B Boppana
Journal:  J Infect Dis       Date:  2010-02-01       Impact factor: 5.226

10.  A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

Authors:  Yoshimi Tsuda; Patrizia Caposio; Christopher J Parkins; Sara Botto; Ilhem Messaoudi; Luka Cicin-Sain; Heinz Feldmann; Michael A Jarvis
Journal:  PLoS Negl Trop Dis       Date:  2011-08-09
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  28 in total

1.  Eradicating infectious disease using weakly transmissible vaccines.

Authors:  Scott L Nuismer; Benjamin M Althouse; Ryan May; James J Bull; Sean P Stromberg; Rustom Antia
Journal:  Proc Biol Sci       Date:  2016-10-26       Impact factor: 5.349

Review 2.  Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates.

Authors:  John J Suschak; Connie S Schmaljohn
Journal:  Hum Vaccin Immunother       Date:  2019-10-07       Impact factor: 3.452

Review 3.  Intratumoral infection by CMV may change the tumor environment by directly interacting with tumor-associated macrophages to promote cancer immunity.

Authors:  Dan A Erkes; Nicole A Wilski; Christopher M Snyder
Journal:  Hum Vaccin Immunother       Date:  2017-06-12       Impact factor: 3.452

Review 4.  Vaccine vectors: the bright side of cytomegalovirus.

Authors:  Andrea C Méndez; Cristina Rodríguez-Rojas; Margarita Del Val
Journal:  Med Microbiol Immunol       Date:  2019-03-21       Impact factor: 3.402

5.  STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity.

Authors:  Nicole A Wilski; Colby Stotesbury; Christina Del Casale; Brian Montoya; Eric Wong; Luis J Sigal; Christopher M Snyder
Journal:  J Immunol       Date:  2020-04-13       Impact factor: 5.422

Review 6.  Fuel and brake of memory T cell inflation.

Authors:  Suzanne P M Welten; Nicolas S Baumann; Annette Oxenius
Journal:  Med Microbiol Immunol       Date:  2019-03-09       Impact factor: 4.148

7.  Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection.

Authors:  Andrea Marzi; Aisling A Murphy; Friederike Feldmann; Christopher J Parkins; Elaine Haddock; Patrick W Hanley; Matthew J Emery; Flora Engelmann; Ilhem Messaoudi; Heinz Feldmann; Michael A Jarvis
Journal:  Sci Rep       Date:  2016-02-15       Impact factor: 4.379

8.  Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey.

Authors:  Heeyoung An; Doo-Wan Cho; Seung Eun Lee; Young-Su Yang; Su-Cheol Han; C Justin Lee
Journal:  Exp Neurobiol       Date:  2016-02-22       Impact factor: 3.261

9.  Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation.

Authors:  Joanne Trgovcich; Michelle Kincaid; Alicia Thomas; Marion Griessl; Peter Zimmerman; Varun Dwivedi; Valerie Bergdall; Paul Klenerman; Charles H Cook
Journal:  PLoS One       Date:  2016-11-21       Impact factor: 3.240

Review 10.  Self-disseminating vaccines for emerging infectious diseases.

Authors:  Aisling A Murphy; Alec J Redwood; Michael A Jarvis
Journal:  Expert Rev Vaccines       Date:  2015-11-02       Impact factor: 5.217
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