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Literature DB >> 25819611

Visually cued action timing in the primary visual cortex.

Vijay Mohan K Namboodiri¹, Marco A Huertas², Kevin J Monk¹, Harel Z Shouval², Marshall G Hussain Shuler³.

Abstract

Most behaviors are generated in three steps: sensing the external world, processing that information to instruct decision-making, and producing a motor action. Sensory areas, especially primary sensory cortices, have long been held to be involved only in the first step of this sequence. Here, we develop a visually cued interval timing task that requires rats to decide when to perform an action following a brief visual stimulus. Using single-unit recordings and optogenetics in this task, we show that activity generated by the primary visual cortex (V1) embodies the target interval and may instruct the decision to time the action on a trial-by-trial basis. A spiking neuronal model of local recurrent connections in V1 produces neural responses that predict and drive the timing of future actions, rationalizing our observations. Our data demonstrate that the primary visual cortex may contribute to the instruction of visually cued timed actions.

Entities: Chemical Disease Gene Species

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Channelrhodopsins

Year: 2015 PMID： 25819611 PMCID： PMC4393368 DOI： 10.1016/j.neuron.2015.02.043

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

54 in total

Visually cued action timing in the primary visual cortex.

Review 1. What makes us tick? Functional and neural mechanisms of interval timing.

Review 2. Distributed hierarchical processing in the primate cerebral cortex.

3. Learning reward timing in cortex through reward dependent expression of synaptic plasticity.

4. Segregation of form, color, and stereopsis in primate area 18.

5. Receptive fields and functional architecture of monkey striate cortex.

Review 6. Topography of cognition: parallel distributed networks in primate association cortex.

7. Mouse primary visual cortex is used to detect both orientation and contrast changes.

8. Modulation of visual responses by behavioral state in mouse visual cortex.

9. Representation of reward feedback in primate auditory cortex.

10. Reward facilitates tactile judgments and modulates hemodynamic responses in human primary somatosensory cortex.

1. Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex.

2. Cortical neurons multiplex reward-related signals along with sensory and motor information.

Review 3. A Dynamical Systems Perspective on Flexible Motor Timing.

4. The Timing of Reward-Seeking Action Tracks Visually Cued Theta Oscillations in Primary Visual Cortex.

5. Encoding Time in Feedforward Trajectories of a Recurrent Neural Network Model.

6. Neurocomputational Models of Interval and Pattern Timing.

Review 7. A gustocentric perspective to understanding primary sensory cortices.

8. Timing in the visual cortex and its investigation.

9. Reward Timing and Its Expression by Inhibitory Interneurons in the Mouse Primary Visual Cortex.

10. A Simple Network Architecture Accounts for Diverse Reward Time Responses in Primary Visual Cortex.