Matthew O Gribble1, Scott M Bartell2, Kurunthachalam Kannan3, Qian Wu4, Patricia A Fair5, Diane L Kamen6. 1. Department of Preventive Medicine, Division of Biostatistics, University of Southern California, Los Angeles, CA, USA. Electronic address: mgribble@usc.edu. 2. Program in Public Health and Department of Statistics; University of California, Irvine, Irvine, CA, USA. 3. Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA. 4. Wadsworth Center, New York State Department of Health, Albany, NY, USA. 5. National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health & Biomolecular Research, Charleston, SC, USA. 6. Department of Medicine, Division of Rheumatology, Medical University of South Carolina; Charleston, SC, USA.
Abstract
BACKGROUND: Charleston Harbor has elevated concentrations of PFAS in dolphins, but local human exposure data are limited. OBJECTIVES: We sought to describe PFAS serum concentrations' temporal trends among Gullah African American residents of coastal South Carolina. METHODS: Longitudinal measures of PFAS in blood serum from a Gullah clinical sample, without lupus, were examined using spaghetti plots and visit-to-visit change scores (e.g., differences in concentrations between visits) among the 68 participants with repeated measures available. We also modeled population-level trends among the 71 participants with any data using proportionate percentile models, accounting for clustering through robust standard errors. In a post-hoc analysis we examined heterogeneity of temporal trends by age through mixed-effects models for the log-transformed PFAS compounds. RESULTS: Population concentrations of PFOS dropped approximately 9 (95% CI: 8, 10) percent each year over 2003-2013. This was concordant with individual PFOS trajectories (median PFOS change score -21.7 ng/g wet weight, interquartile range of PFOS change scores: -32.8, -14.9) and reports for other populations over this time period. Several other compounds including PFOA, PFHxS, and PFuNDA also showed a population-level decrease. However, examination of individual trajectories suggested substantial heterogeneity. Post-hoc analyses indicated that PFAS trajectories were heterogeneous by age. CONCLUSIONS: Many PFAS compounds are decreasing in a sample of Gullah African Americans from coastal South Carolina. There may be age differences in the elimination kinetics of PFASs. The possible role of age as a modifier of PFAS serum trends merits further research.
BACKGROUND: Charleston Harbor has elevated concentrations of PFAS in dolphins, but local human exposure data are limited. OBJECTIVES: We sought to describe PFAS serum concentrations' temporal trends among Gullah African American residents of coastal South Carolina. METHODS: Longitudinal measures of PFAS in blood serum from a Gullah clinical sample, without lupus, were examined using spaghetti plots and visit-to-visit change scores (e.g., differences in concentrations between visits) among the 68 participants with repeated measures available. We also modeled population-level trends among the 71 participants with any data using proportionate percentile models, accounting for clustering through robust standard errors. In a post-hoc analysis we examined heterogeneity of temporal trends by age through mixed-effects models for the log-transformed PFAS compounds. RESULTS: Population concentrations of PFOS dropped approximately 9 (95% CI: 8, 10) percent each year over 2003-2013. This was concordant with individual PFOS trajectories (median PFOS change score -21.7 ng/g wet weight, interquartile range of PFOS change scores: -32.8, -14.9) and reports for other populations over this time period. Several other compounds including PFOA, PFHxS, and PFuNDA also showed a population-level decrease. However, examination of individual trajectories suggested substantial heterogeneity. Post-hoc analyses indicated that PFAS trajectories were heterogeneous by age. CONCLUSIONS: Many PFAS compounds are decreasing in a sample of Gullah African Americans from coastal South Carolina. There may be age differences in the elimination kinetics of PFASs. The possible role of age as a modifier of PFAS serum trends merits further research.
Authors: Magali Houde; Randall S Wells; Patricia A Fair; Greg D Bossart; Aleta A Hohn; Teri K Rowles; Jay C Sweeney; Keith R Solomon; Derek C G Muir Journal: Environ Sci Technol Date: 2005-09-01 Impact factor: 9.028
Authors: Kurunthachalam Kannan; Simonetta Corsolini; Jerzy Falandysz; Gilberto Fillmann; Kurunthachalam Senthil Kumar; Bommanna G Loganathan; Mustafa Ali Mohd; Jesus Olivero; Nathalie Van Wouwe; Jae Ho Yang; Kenneth M Aldoust Journal: Environ Sci Technol Date: 2004-09-01 Impact factor: 9.028
Authors: Katie M Lynch; Patricia A Fair; Magali Houde; Derek C G Muir; Kurunthachalam Kannan; Gregory D Bossart; Scott M Bartell; Matthew O Gribble Journal: Environ Sci Technol Date: 2019-12-05 Impact factor: 9.028
Authors: Matthew C Hamilton; Melissa M Heintz; Marisa Pfohl; Emily Marques; Lucie Ford; Angela L Slitt; William S Baldwin Journal: Food Chem Toxicol Date: 2021-04-08 Impact factor: 5.572
Authors: Xindi C Hu; Andrea K Tokranov; Jahred Liddie; Xianming Zhang; Philippe Grandjean; Jaime E Hart; Francine Laden; Qi Sun; Leo W Y Yeung; Elsie M Sunderland Journal: Environ Health Perspect Date: 2019-06-06 Impact factor: 9.031
Authors: Emmanuel Dartey; Dag G Ellingsen; Balazs Berlinger; Yngvar Thomassen; Jon Ø Odland; Jan Brox; Vincent K Nartey; Francis A Yeboah; Sandra Huber Journal: Int J Environ Res Public Health Date: 2021-02-08 Impact factor: 3.390
Authors: Michael C Petriello; M Abdul Mottaleb; Tara C Serio; Bharat Balyan; Matthew C Cave; Marian Pavuk; Linda S Birnbaum; Andrew J Morris Journal: Environ Int Date: 2021-11-08 Impact factor: 13.352