Literature DB >> 25819086

Large noncoding RNAs are promising regulators in embryonic stem cells.

Ya-Pu Li1, Yangming Wang2.   

Abstract

Embryonic stem cells (ESCs) hold great promises for treating and studying numerous devastating diseases. The molecular basis of their potential is not completely understood. Large noncoding RNAs (lncRNAs) are an important class of gene regulators that play essential roles in a variety of physiologic and pathologic processes. Dozens of lncRNAs are now identified to control ESC self-renewal and differentiation. Research on lncRNAs may provide novel insights into manipulating the cell fate or reprogramming somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the recent research efforts in identifying functional lncRNAs and understanding how they act in ESCs, and discuss various future directions of this field.
Copyright © 2015 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Keywords:  Differentiation; Embryonic stem cells; Induced pluripotent stem cells; Large noncoding RNAs; Self-renewal

Mesh：

Substances：

Year:  2015        PMID： 25819086     DOI： 10.1016/j.jgg.2015.02.002

Source DB:  PubMed          Journal:  J Genet Genomics        ISSN： 1673-8527            Impact factor:   4.275


  8 in total

1.  Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro.

Authors:  Jingying Hou; Huibao Long; Changqing Zhou; Shaoxin Zheng; Hao Wu; Tianzhu Guo; Quanhua Wu; Tingting Zhong; Tong Wang
Journal:  Stem Cell Res Ther       Date:  2017-01-17       Impact factor: 6.832

Review 2.  Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells.

Authors:  Gregory M Kelly; Mohamed I Gatie
Journal:  Stem Cells Int       Date:  2017-03-08       Impact factor: 5.443

Review 3.  Non-coding RNAs are promising targets for stem cell-based cancer therapy.

Authors:  Naoya Sakamoto; Ririno Honma; Yohei Sekino; Keisuke Goto; Kazuhiro Sentani; Akira Ishikawa; Naohide Oue; Wataru Yasui
Journal:  Noncoding RNA Res       Date:  2017-05-22

4.  Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation.

Authors:  Hai-Lin Pang; Qian-Qian Zhao; Yu Ma; Yong-Li Song; Jie Min; Jian-Rong Lu; Hang Li; Da-Qing Zhao
Journal:  Stem Cells Int       Date:  2019-05-05       Impact factor: 5.443

5.  A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis.

Authors:  Yilu Qin; Yixuan Hou; Shuiqing Liu; Pengpeng Zhu; Xueying Wan; Maojia Zhao; Meixi Peng; Huan Zeng; Qiao Li; Ting Jin; Xiaojiang Cui; Manran Liu
Journal:  Adv Sci (Weinh)       Date:  2020-11-30       Impact factor: 17.521

6.  LncRNA BCAR4 promotes colon cancer progression via activating Wnt/β-catenin signaling.

Authors:  Shurui Ouyang; Xinbin Zheng; Xin Zhou; Zhengquan Chen; Xuefeng Yang; Ming Xie
Journal:  Oncotarget       Date:  2017-10-06

Review 7.  lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration.

Authors:  Jian Zhu; Wei Yu; Yitian Wang; Kaishun Xia; Yuluan Huang; Ankai Xu; Qixin Chen; Bing Liu; Huimin Tao; Fangcai Li; Chengzhen Liang
Journal:  Stem Cell Res Ther       Date:  2019-11-21       Impact factor: 6.832

8.  Genome-wide interaction target profiling reveals a novel Peblr20-eRNA activation pathway to control stem cell pluripotency.

Authors:  Cong Wang; Lin Jia; Yichen Wang; Zhonghua Du; Lei Zhou; Xue Wen; Hui Li; Shilin Zhang; Huiling Chen; Naifei Chen; Jingcheng Chen; Yanbo Zhu; Yuanyuan Nie; Ilkay Celic; Sujun Gao; Songling Zhang; Andrew R Hoffman; Wei Li; Ji-Fan Hu; Jiuwei Cui
Journal:  Theranostics       Date:  2020-01-01       Impact factor: 11.556
  8 in total

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