Literature DB >> 25818365

Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.

Josette M Northcott1, Jason J Northey2, J Matthew Barnes2, Valerie M Weaver3.   

Abstract

Tumor cells exist in a constantly evolving stromal microenvironment composed of vasculature, immune cells and cancer-associated fibroblasts, all residing within a dynamic extracellular matrix. In this review, we examine the biochemical and biophysical interactions between these various stromal cells and their matrix microenvironment. While the stroma can alter tumor progression via multiple mechanisms, we emphasize the role of homeobox genes in detecting and modulating the mechanical changes in the microenvironment during tumor progression.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Extracellular matrix; Homeobox genes; Stiffness; Stromal cells; Tumor microenvironment

Mesh：

Substances：

Year:  2015        PMID： 25818365      PMCID： PMC4433566          DOI： 10.1016/j.bbcan.2015.03.004

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  59 in total

1.  A role for Hox A5 in regulating angiogenesis and vascular patterning.

Authors:  Kim Rhoads; Gemma Arderiu; Aubri Charboneau; Scott L Hansen; William Hoffman; Nancy Boudreau
Journal:  Lymphat Res Biol       Date:  2005       Impact factor: 2.589

2.  Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells.

Authors:  A Srebrow; Y Friedmann; A Ravanpay; C W Daniel; M J Bissell
Journal:  J Cell Biochem       Date:  1998-06-15       Impact factor: 4.429

Review 3.  The extracellular matrix modulates the hallmarks of cancer.

Authors:  Michael W Pickup; Janna K Mouw; Valerie M Weaver
Journal:  EMBO Rep       Date:  2014-11-08       Impact factor: 8.807

4.  Tensional homeostasis and the malignant phenotype.

Authors:  Matthew J Paszek; Nastaran Zahir; Kandice R Johnson; Johnathon N Lakins; Gabriela I Rozenberg; Amit Gefen; Cynthia A Reinhart-King; Susan S Margulies; Micah Dembo; David Boettiger; Daniel A Hammer; Valerie M Weaver
Journal:  Cancer Cell       Date:  2005-09       Impact factor: 31.743

5.  Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model.

Authors:  Meritxell Carrio; Gemma Arderiu; Connie Myers; Nancy J Boudreau
Journal:  Cancer Res       Date:  2005-08-15       Impact factor: 12.701

6.  Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

Authors:  Antonia Patsialou; Jeffrey Wyckoff; Yarong Wang; Sumanta Goswami; E Richard Stanley; John S Condeelis
Journal:  Cancer Res       Date:  2009-12-15       Impact factor: 12.701

7.  Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Authors:  Kandice R Levental; Hongmei Yu; Laura Kass; Johnathon N Lakins; Mikala Egeblad; Janine T Erler; Sheri F T Fong; Katalin Csiszar; Amato Giaccia; Wolfgang Weninger; Mitsuo Yamauchi; David L Gasser; Valerie M Weaver
Journal:  Cell       Date:  2009-11-25       Impact factor: 41.582

8.  A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.

Authors:  Min Yu; Gromoslaw A Smolen; Jianmin Zhang; Ben Wittner; Benjamin J Schott; Elena Brachtel; Sridhar Ramaswamy; Shyamala Maheswaran; Daniel A Haber
Journal:  Genes Dev       Date:  2009-08-01       Impact factor: 11.361

9.  Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.

Authors:  Bruno M Costa; Justin S Smith; Ying Chen; Justin Chen; Heidi S Phillips; Kenneth D Aldape; Giuseppe Zardo; Janice Nigro; C David James; Jane Fridlyand; Rui M Reis; Joseph F Costello
Journal:  Cancer Res       Date:  2010-01-12       Impact factor: 12.701

10.  The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling.

Authors:  Douglas S Micalizzi; Kimberly L Christensen; Paul Jedlicka; Ricardo D Coletta; Anna E Barón; J Chuck Harrell; Kathryn B Horwitz; Dean Billheimer; Karen A Heichman; Alana L Welm; William P Schiemann; Heide L Ford
Journal:  J Clin Invest       Date:  2009-08-24       Impact factor: 14.808
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  5 in total

1.  Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.

Authors:  Kang-Jin Park; Sung-Bum Cho; Young-Lan Park; Nuri Kim; Sun-Young Park; Dae-Seong Myung; Wan-Sik Lee; Sun-Seog Kweon; Young-Eun Joo
Journal:  Gastric Cancer       Date:  2016-01-12       Impact factor: 7.370

Review 2.  Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment.

Authors:  Yanming Luo; Shuangshuang Yin; Jia Lu; Shiyue Zhou; Yingying Shao; Xiaomei Bao; Tao Wang; Yuling Qiu; Haiyang Yu
Journal:  Cancer Cell Int       Date:  2021-07-20       Impact factor: 5.722

3.  Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane.

Authors:  Thomas T Y Wang; Quynhchi Pham; Young S Kim
Journal:  Int J Mol Sci       Date:  2018-01-24       Impact factor: 5.923

Review 4.  A Case of Identity: HOX Genes in Normal and Cancer Stem Cells.

Authors:  Jessica Smith; Ahmad Zyoud; Cinzia Allegrucci
Journal:  Cancers (Basel)       Date:  2019-04-10       Impact factor: 6.639

5.  Epigenome-Wide Association Study of Prostate Cancer in African Americans Identifies DNA Methylation Biomarkers for Aggressive Disease.

Authors:  Yifan Xu; Chia-Wen Tsai; Wen-Shin Chang; Yuyan Han; Maosheng Huang; Curtis A Pettaway; Da-Tian Bau; Jian Gu
Journal:  Biomolecules       Date:  2021-12-03
  5 in total

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