Miguel Angel Arrabal-Polo1, María Sierra Girón-Prieto2, María Del Carmen Cano-García3, Antonio Poyatos-Andujar4, Miguel Quesada-Charneco5, Felix Abad-Menor6, Salvador Arias-Santiago7, Armando Zuluaga-Gomez6, Miguel Arrabal-Martin6. 1. Servicio de Urología, Hospital La Inmaculada, Huercal-Overa, Spain. Electronic address: arrabalp@ono.com. 2. Centro de Salud de Atarfe, Spain; Programa de Doctorado de Medicina Clínica y Salud Pública, Universidad de Granada, Spain. 3. Servicio de Urología, Hospital La Inmaculada, Huercal-Overa, Spain. 4. Servicio de Analisis Clinicos, Hospital Universitario San Cecilio, Granada, Spain. 5. Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, Spain. 6. Servicio de Urología, Hospital Universitario San Cecilio, IBS Granada, Granada, Spain. 7. Departamento de Medicina, Universidad de Granada, Spain.
Abstract
OBJECTIVE: To analyze differences in bone remodeling markers, lithogenic factors and bone densitometry among the 3 groups of patients (controls, patients with relapsing calcium renal lithiasis, and patients with loss of bone mineral density without lithiasis). MATERIAL AND METHODS: This is a cross-sectional study including 203 patients who were divided in 3 groups: group 1 (controls), group 2 (patients with relapsing calcium renal lithiasis), and group 3 (patients with osteopenia and/or osteoporosis in the lumbar spine or hip). Bone densitometry, calcium-phosphorous and bone metabolism analysis, and analysis of lithogenic risk factors in fasting urine samples and 24-hour urine samples were performed. Statistical analysis was performed with SPSS 17.0. A P ≤.05 was considered statistically significant. RESULTS: Patients in group 2 presented greater calcium excretion and a lower citrate excretion in 24-hour urine samples as compared with the other 2 groups. The proportion of hypercalciuria and hypocitraturia was higher in group 2. In addition, patients in group 2 presented a lower loss of bone mineral density as well as altered bone remodeling markers as compared with those in group 1. Patients in group 3 also presented alterations in urine calcium and citrate excretion with respect to the control group, with elevated fasting calcium and citrate levels and calcium-to-citrateratio. CONCLUSION: Lithogenic risk factors are altered in patients with osteopenia and/or osteoporosis without renal lithiasis although to a lesser extent than patients with calcium renal lithiasis.
OBJECTIVE: To analyze differences in bone remodeling markers, lithogenic factors and bone densitometry among the 3 groups of patients (controls, patients with relapsing calciumrenal lithiasis, and patients with loss of bone mineral density without lithiasis). MATERIAL AND METHODS: This is a cross-sectional study including 203 patients who were divided in 3 groups: group 1 (controls), group 2 (patients with relapsing calciumrenal lithiasis), and group 3 (patients with osteopenia and/or osteoporosis in the lumbar spine or hip). Bone densitometry, calcium-phosphorous and bone metabolism analysis, and analysis of lithogenic risk factors in fasting urine samples and 24-hour urine samples were performed. Statistical analysis was performed with SPSS 17.0. A P ≤.05 was considered statistically significant. RESULTS:Patients in group 2 presented greater calcium excretion and a lower citrate excretion in 24-hour urine samples as compared with the other 2 groups. The proportion of hypercalciuria and hypocitraturia was higher in group 2. In addition, patients in group 2 presented a lower loss of bone mineral density as well as altered bone remodeling markers as compared with those in group 1. Patients in group 3 also presented alterations in urine calcium and citrate excretion with respect to the control group, with elevated fasting calcium and citrate levels and calcium-to-citrateratio. CONCLUSION: Lithogenic risk factors are altered in patients with osteopenia and/or osteoporosis without renal lithiasis although to a lesser extent than patients with calciumrenal lithiasis.
Authors: P Lucato; C Trevisan; B Stubbs; B M Zanforlini; M Solmi; C Luchini; G Girotti; S Pizzato; E Manzato; G Sergi; S Giannini; M Fusaro; N Veronese Journal: Osteoporos Int Date: 2016-06-11 Impact factor: 4.507