Literature DB >> 2581566

n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog.

K Karikó, J Ludwig.   

Abstract

n-Decyl-NHpppA2'p5'A2'p5'A, a gamma-substituted, phosphatase-resistant pppA2'p5'A2'p5'A analog, gives similar rRNA degradation pattern in interferon-treated HeLa cell extracts--even at a concentration of 10(-9)M--as the natural compound does.

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Year:  1985        PMID： 2581566     DOI： 10.1016/0006-291x(85)90102-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Chemical synthesis and biological activities of analogues of 2',5'-oligoadenylates containing 8-substituted adenosine derivatives.

Authors:  M Kanou; H Ohomori; H Takaku; S Yokoyama; G Kawai; R J Suhadolnik; R Sobol
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

2.  The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation.

Authors:  C Bisbal; M Silhol; H Laubenthal; T Kaluza; G Carnac; L Milligan; F Le Roy; T Salehzada
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

3.  Interferon induction by adenovirus type 12: stimulatory function of early region 1A.

Authors:  M I Toth; B Arya; R Pusztai; K Shiroki; I Beladi
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103

Review 4.  The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.

Authors:  M R Player; P F Torrence
Journal:  Pharmacol Ther       Date:  1998-05       Impact factor: 12.310
  4 in total

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