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Literature DB >> 25815159

Phenolic diterpenoid derivatives as anti-influenza a virus agents.

Zhao Dang¹, Katherine Jung¹, Lei Zhu¹, Hua Xie², Kuo-Hsiung Lee³, Chin-Ho Chen¹, Li Huang¹.

Abstract

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

Entities: Chemical Disease Species

Keywords: Influenza A; hemagglutinin; influenza inhibitor; podocarpic acid; totarol

Year: 2015 PMID： 25815159 PMCID： PMC4360168 DOI： 10.1021/ml500533x

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

21 in total

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Journal: Microbes Infect Date: 2001-01 Impact factor: 2.700

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Authors: Sheo B Singh; John G Ondeyka; Weiguo Liu; Steve Chen; Tom S Chen; Xiaohua Li; Aileen Bouffard; James Dropinski; A Brian Jones; Sherrie McCormick; Nancy Hayes; Jianhua Wang; Neelam Sharma; Karen Macnaul; Melba Hernandez; Yu-Sheng Chao; Joanne Baffic; My-Hanh Lam; Charlotte Burton; Carl P Sparrow; John G Menke
Journal: Bioorg Med Chem Lett Date: 2005-06-02 Impact factor: 2.823

Review 3. Antivirals targeting influenza A virus.

Authors: Kalyan Das
Journal: J Med Chem Date: 2012-06-04 Impact factor: 7.446

4. Design, synthesis and characterization of podocarpate derivatives as openers of BK channels.

Authors: Yong-Mei Cui; Eriko Yasutomi; Yuko Otani; Takashi Yoshinaga; Katsutoshi Ido; Kohei Sawada; Tomohiko Ohwada
Journal: Bioorg Med Chem Lett Date: 2008-08-28 Impact factor: 2.823

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Authors: Kalyan Das; James M Aramini; Li-Chung Ma; Robert M Krug; Eddy Arnold
Journal: Nat Struct Mol Biol Date: 2010-04-11 Impact factor: 15.369

Review 7. Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials.

Authors: Mark H Ebell; Marlene Call; JoAnna Shinholser
Journal: Fam Pract Date: 2012-09-20 Impact factor: 2.267

8. Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus.

Authors: H Muroi; I Kubo
Journal: J Appl Bacteriol Date: 1996-04

Phenolic diterpenoid derivatives as anti-influenza a virus agents.

1. The 1918 Spanish influenza: integrating history and biology.

2. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.

Review 3. Antivirals targeting influenza A virus.

4. Design, synthesis and characterization of podocarpate derivatives as openers of BK channels.

Review 5. Global epidemiology of influenza: past and present.

Review 6. Structures of influenza A proteins and insights into antiviral drug targets.

Review 7. Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials.

8. Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus.

Review 9. Antiviral strategies against influenza virus: towards new therapeutic approaches.

10. Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin.

1. Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.

Review 2. Progress of small molecular inhibitors in the development of anti-influenza virus agents.

3. Anti-influenza virus activity of extracts from the stems of Jatropha multifida Linn. collected in Myanmar.

Review 4. Small Molecule Inhibitors of Influenza Virus Entry.