Literature DB >> 25814687

Getting to the heart of the matter: new insights into cardiac fibrosis.

Andrew Leask1.   

Abstract

Fibrotic diseases are a significant global burden for which there are limited treatment options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly contractile cell type characterized by the appearance of α-smooth muscle actin stress fibers. The underlying mechanism behind myofibroblast differentiation and persistence has been under much investigation and is known to involve a complex signaling network involving transforming growth factor-β, endothelin-1, angiotensin II, CCN2 (connective tissue growth factor), and platelet-derived growth factor. This review addresses the contribution of these signaling molecules to cardiac fibrosis.
© 2015 American Heart Association, Inc.

Entities:  

Keywords:  cicatrix; endothelins; fibrosis; platelet-derived growth factor

Mesh：

Substances：

Year:  2015        PMID： 25814687     DOI： 10.1161/CIRCRESAHA.116.305381

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  122 in total

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4.  Gq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a three-dimensional microtissue environment.

Authors:  C M Kofron; T Y Kim; M E King; A Xie; F Feng; E Park; Z Qu; B-R Choi; U Mende
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-07-14       Impact factor: 4.733

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Review 6.  Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling.

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Review 7.  Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?

Authors:  Emily L Ongstad; Robert G Gourdie
Journal:  Semin Cell Dev Biol       Date:  2016-05-24       Impact factor: 7.727

8.  The impacts of age and frailty on heart rate and sinoatrial node function.

Authors:  Motahareh Moghtadaei; Hailey J Jansen; Martin Mackasey; Sara A Rafferty; Oleg Bogachev; John L Sapp; Susan E Howlett; Robert A Rose
Journal:  J Physiol       Date:  2016-10-17       Impact factor: 5.182

9.  The CCN family of proteins: a 25th anniversary picture.

Authors:  Annick Perbal; Bernard Perbal
Journal:  J Cell Commun Signal       Date:  2016-08-31       Impact factor: 5.782

10.  Regenerative biology of tendon: mechanisms for renewal and repair.

Authors:  Nathaniel A Dyment; Jenna L Galloway
Journal:  Curr Mol Biol Rep       Date:  2015-09
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