| Literature DB >> 25814480 |
Ming-Jie Zhang1, Yan-Wei Yin1, Bing-Hu Li1, Yun Liu1, Shao-Qiong Liao1, Chang-Yue Gao1, Jing-Cheng Li1, Li-Li Zhang2.
Abstract
The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Currently, cumulative studies have demonstrated an interesting link between TRPV1 and cardiovascular diseases, including hypertension. Additionally, the protective effect of TRPV1 against hypertension and its related disorders has been proved to be partly involved with the improved action of vascular smooth muscle cells (VSMCs). This review focuses on the current knowledge of TRPV1 in improving VSMC function and attenuating hypertension.Entities:
Keywords: Calcium ion; Hypertension; Inflammation; Neurotransmitters; Transient receptor potential vanilloid type 1; Vascular smooth muscle cells
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Year: 2015 PMID： 25814480 DOI： 10.1016/j.pbiomolbio.2015.03.004
Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667