Literature DB >> 25813715

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.

Jekaterina Ivanova1, Janis Leitans, Muhammet Tanc, Andris Kazaks, Raivis Zalubovskis, Claudiu T Supuran, Kaspars Tars.   

Abstract

1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.

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Year:  2015        PMID： 25813715     DOI： 10.1039/c5cc01854d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons.

Authors:  Yantao Chen; Carl-Johan Aurell; Anna Pettersen; Richard J Lewis; Martin A Hayes; Matti Lepistö; Anna C Jonson; Hanna Leek; Linda Thunberg
Journal:  ACS Med Chem Lett       Date:  2017-05-01       Impact factor: 4.345

2.  ADME properties, bioactivity and molecular docking studies of 4-amino-chalcone derivatives: new analogues for the treatment of Alzheimer, glaucoma and epileptic diseases.

Authors:  Meliha Burcu Gürdere; Yakup Budak; Umit M Kocyigit; Parham Taslimi; Burak Tüzün; Mustafa Ceylan
Journal:  In Silico Pharmacol       Date:  2021-05-03

Review 3.  Non-Classical Inhibition of Carbonic Anhydrase.

Authors:  Carrie L Lomelino; Claudiu T Supuran; Robert McKenna
Journal:  Int J Mol Sci       Date:  2016-07-16       Impact factor: 5.923

4.  Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

Authors:  Melissa D'Ascenzio; Paolo Guglielmi; Simone Carradori; Daniela Secci; Rosalba Florio; Adriano Mollica; Mariangela Ceruso; Atilla Akdemir; Anatoly P Sobolev; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-26       Impact factor: 5.051

5.  Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines.

Authors:  Emre GÜzel; Fatih SÖnmez; Sultan Erkan; Kübra ÇikrikÇi; Adem ErgÜn; Nahit GenÇer; Oktay Arslan; Makbule B KoÇak
Journal:  Turk J Chem       Date:  2020-12-16       Impact factor: 1.239

6.  The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors.

Authors:  Aleksandrs Pustenko; Alessio Nocentini; Paola Gratteri; Alessandro Bonardi; Igor Vozny; Raivis Žalubovskis; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  6 in total

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