Jinxia Zhang1, Yujin Zhang2, Hongwei Liu2, Huai Bai1, Ying Wang2, Changan Jiang1, Ping Fan3. 1. Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 2. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 3. Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: fanping15@scu.edu.cn.
Abstract
OBJECTIVE: To determine the relationships among the inflammatory index, intrinsic oxidation levels, lipid and apolipoprotein (apo)A-I concentrations of high-density lipoprotein (HDL), and polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional study. SETTING: University hospital. PATIENT(S): A total of 425 patients with PCOS and 441 control women were included. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The HDL inflammatory index (HII) was determined using a cell-free fluorometric assay. Intrinsic HDL oxidation levels, HDL-free cholesterol, HDL-cholesterol ester, HDL-triglyceride, serum apoA-I, and malondialdehyde levels were also measured. RESULT(S): The mean HII value and the frequency of HII ≥1 were significantly higher in the PCOS group (0.77 ± 0.54, 27.1%) than in the control group (0.53 ± 0.37, 8.4%). These values were also higher in each of the 4 PCOS phenotypes based on the Rotterdam criteria than in the controls, and higher in patients with hyperandrogenism (HA) + oligo- and/or anovulation (OA) phenotype than in those with OA + polycystic ovary (PCO) phenotype. Furthermore, patients with PCOS with OA + PCO had lower malondialdehyde and intrinsic HDL oxidation levels compared with those with HA. Multivariate regression analysis demonstrated that PCOS, HDL-cholesterol ester, and E2 levels were the main predictors of HII value. CONCLUSION(S): The impairment of HDL antioxidant/anti-inflammatory function in PCOS is related to HA status, increased oxidative stress, and abnormalities in HDL components and thus may contribute to PCOS pathogenesis and increase the risks of future cardiovascular diseases.
OBJECTIVE: To determine the relationships among the inflammatory index, intrinsic oxidation levels, lipid and apolipoprotein (apo)A-I concentrations of high-density lipoprotein (HDL), and polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional study. SETTING: University hospital. PATIENT(S): A total of 425 patients with PCOS and 441 control women were included. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The HDL inflammatory index (HII) was determined using a cell-free fluorometric assay. Intrinsic HDL oxidation levels, HDL-free cholesterol, HDL-cholesterol ester, HDL-triglyceride, serum apoA-I, and malondialdehyde levels were also measured. RESULT(S): The mean HII value and the frequency of HII ≥1 were significantly higher in the PCOS group (0.77 ± 0.54, 27.1%) than in the control group (0.53 ± 0.37, 8.4%). These values were also higher in each of the 4 PCOS phenotypes based on the Rotterdam criteria than in the controls, and higher in patients with hyperandrogenism (HA) + oligo- and/or anovulation (OA) phenotype than in those with OA + polycystic ovary (PCO) phenotype. Furthermore, patients with PCOS with OA + PCO had lower malondialdehyde and intrinsic HDL oxidation levels compared with those with HA. Multivariate regression analysis demonstrated that PCOS, HDL-cholesterol ester, and E2 levels were the main predictors of HII value. CONCLUSION(S): The impairment of HDL antioxidant/anti-inflammatory function in PCOS is related to HA status, increased oxidative stress, and abnormalities in HDL components and thus may contribute to PCOS pathogenesis and increase the risks of future cardiovascular diseases.
Authors: S Contreras-Duarte; P Chen; M Andía; S Uribe; P Irarrázaval; S Kopp; S Kern; G Marsche; D Busso; C Wadsack; A Rigotti Journal: Biol Res Date: 2018-09-15 Impact factor: 5.612
Authors: Jandui Escariãoda Nóbrega; Joabel Tonelotto Dos Santos; Lady K Serrano-Mujica; Guilherme Bochi; Rafael Noal Moresco; Vitor Braga Rissi; Werner Giehl Glanzner; Felipe W Langer; Alfredo Quites Antoniazzi; Paulo Bayard Dias Gonçalves; Melissa O Premaor; Fabio V Comim Journal: J Inflamm Res Date: 2019-03-06
Authors: Robertha Mariana R Lemes; Carlos Adriano de M E Silva; Maria Ângela de M Marques; Georgia C Atella; José Augusto da C Nery; Maria Renata S Nogueira; Patricia S Rosa; Cléverson T Soares; Prithwiraj De; Delphi Chatterjee; Maria Cristina V Pessolani; Cristiana S de Macedo Journal: PLoS Negl Trop Dis Date: 2020-03-30