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Literature DB >> 25812520

Energy stress tames the Hippo pathway.

Abstract

The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.

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Year: 2015 PMID： 25812520 DOI： 10.1038/ncb3141

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

16 in total

Review 1. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis.

Authors: D Grahame Hardie
Journal: Curr Opin Cell Biol Date: 2014-09-26 Impact factor: 8.382

Review 2. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment.

Authors: Randy Johnson; Georg Halder
Journal: Nat Rev Drug Discov Date: 2013-12-13 Impact factor: 84.694

3. Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.

Authors: Michael DeRan; Jiayi Yang; Che-Hung Shen; Eric C Peters; Julien Fitamant; Puiyee Chan; Mindy Hsieh; Shunying Zhu; John M Asara; Bin Zheng; Nabeel Bardeesy; Jun Liu; Xu Wu
Journal: Cell Rep Date: 2014-10-16 Impact factor: 9.423

4. A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription.

Authors: Yijun Bao; Kentaro Nakagawa; Zeyu Yang; Mitsunobu Ikeda; Kanchanamala Withanage; Mari Ishigami-Yuasa; Yukiko Okuno; Shoji Hata; Hiroshi Nishina; Yutaka Hata
Journal: J Biochem Date: 2011-05-17 Impact factor: 3.387

5. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Authors: Yi Liu-Chittenden; Bo Huang; Joong Sup Shim; Qian Chen; Se-Jin Lee; Robert A Anders; Jun O Liu; Duojia Pan
Journal: Genes Dev Date: 2012-06-07 Impact factor: 11.361

6. YAP1 increases organ size and expands undifferentiated progenitor cells.

Authors: Fernando D Camargo; Sumita Gokhale; Jonathan B Johnnidis; Dongdong Fu; George W Bell; Rudolf Jaenisch; Thijn R Brummelkamp
Journal: Curr Biol Date: 2007-11-01 Impact factor: 10.834

7. Elucidation of a universal size-control mechanism in Drosophila and mammals.

Authors: Jixin Dong; Georg Feldmann; Jianbin Huang; Shian Wu; Nailing Zhang; Sarah A Comerford; Mariana F Gayyed; Robert A Anders; Anirban Maitra; Duojia Pan
Journal: Cell Date: 2007-09-21 Impact factor: 41.582

Review 8. The biology of YAP/TAZ: hippo signaling and beyond.

Authors: Stefano Piccolo; Sirio Dupont; Michelangelo Cordenonsi
Journal: Physiol Rev Date: 2014-10 Impact factor: 37.312

9. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

Authors: Nailing Zhang; Haibo Bai; Karen K David; Jixin Dong; Yonggang Zheng; Jing Cai; Marco Giovannini; Pentao Liu; Robert A Anders; Duojia Pan
Journal: Dev Cell Date: 2010-07-20 Impact factor: 12.270

10. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.

Authors: Jung-Soon Mo; Zhipeng Meng; Young Chul Kim; Hyun Woo Park; Carsten Gram Hansen; Soohyun Kim; Dae-Sik Lim; Kun-Liang Guan
Journal: Nat Cell Biol Date: 2015-03-09 Impact factor: 28.824

4 in total

1. The sweet side of YAP/TAZ.

Authors: Giulia Santinon; Elena Enzo; Sirio Dupont
Journal: Cell Cycle Date: 2015-06-26 Impact factor: 4.534

Review 2. Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis.

Authors: Taha Azad; Reza Rezaei; Abera Surendran; Ragunath Singaravelu; Stephen Boulton; Jaahnavi Dave; John C Bell; Carolina S Ilkow
Journal: Cancers (Basel) Date: 2020-07-24 Impact factor: 6.639

3. YAP Dictates Mitochondrial Redox Homeostasis to Facilitate Obesity-Associated Breast Cancer Progression.

Authors: Jia-Zih Dai; Yen-Ju Wang; Cheng-Hsun Chen; I-Lin Tsai; Yi-Chun Chao; Cheng-Wei Lin
Journal: Adv Sci (Weinh) Date: 2022-02-18 Impact factor: 17.521

4. Microbiota Perturbation or Elimination Can Inhibit Normal Development and Elicit a Starvation-Like Response in an Omnivorous Model Invertebrate.

Authors: Arturo Vera-Ponce de León; Benjamin C Jahnes; Alejandro Otero-Bravo; Zakee L Sabree
Journal: mSystems Date: 2021-08-24 Impact factor: 6.496

4 in total