Literature DB >> 2581185

Stereoselectivity of L-baclofen in hippocampal slices of the rat.

H L Haas, R W Greene, H R Olpe.   

Abstract

Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 microM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the L- none in the D-enantiomer. D-BF did not antagonize the action of L-BF.

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Year:  1985        PMID： 2581185     DOI： 10.1016/0304-3940(85)90302-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.

Authors:  G Ochs; A Struppler; B A Meyerson; B Linderoth; J Gybels; B P Gardner; P Teddy; A Jamous; P Weinmann
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-08       Impact factor: 10.154

2.  Blockade of gamma-aminobutyric acid-receptors of the B-subtype inhibits the dopamine-induced enhancement of the release of cholecystokinin-like immunoreactivity from slices of rat dorsal caudatoputamen.

Authors:  U Conzelmann; D K Meyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

3.  Stimulation of receptors of gamma-aminobutyric acid modulates the release of cholecystokinin-like immunoreactivity from slices of rat neostriatum.

Authors:  U Conzelmann; D K Meyer; G Sperk
Journal:  Br J Pharmacol       Date:  1986-12       Impact factor: 8.739

4.  GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.

Authors:  G D Frye; T J McCown; G R Breese; S L Peterson
Journal:  J Pharmacol Exp Ther       Date:  1986-05       Impact factor: 4.030

5.  Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption.

Authors:  Chelsea R Kasten; Shelby N Blasingame; Stephen L Boehm
Journal:  Alcohol       Date:  2014-12-17       Impact factor: 2.405

6.  Reduction by baclofen of monosynaptic EPSPs in lumbosacral motoneurones of the anaesthetized cat.

Authors:  F R Edwards; P J Harrison; J J Jack; D M Kullmann
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

Review 7.  Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.

Authors:  J R Howe; B Sutor; W Zieglgänsberger
Journal:  J Physiol       Date:  1987-03       Impact factor: 5.182

8.  Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution.

Authors:  R Paredes; A Agmo
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

Review 9.  Fragile X syndrome: an update on developing treatment modalities.

Authors:  Aileen Healy; Roger Rush; Timothy Ocain
Journal:  ACS Chem Neurosci       Date:  2011-03-22       Impact factor: 4.418
  9 in total

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