Literature DB >> 25810312

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

Cameron McDonald-Hyman1, Laurence A Turka2, Bruce R Blazar3.   

Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.
Copyright © 2015, American Association for the Advancement of Science.

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Year:  2015        PMID： 25810312      PMCID： PMC4425354          DOI： 10.1126/scitranslmed.aaa6853

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  118 in total

1.  Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates.

Authors:  Dominic C Borie; Paul S Changelian; Michael J Larson; Ming-Sing Si; Ricardo Paniagua; John P Higgins; Bari Holm; Andrew Campbell; Macy Lau; Sally Zhang; Mona G Flores; Geraldine Rousvoal; Jennifer Hawkins; Douglas A Ball; Elizabeth M Kudlacz; William H Brissette; Eileen A Elliott; Bruce A Reitz; Randall E Morris
Journal:  Transplantation       Date:  2005-04-15       Impact factor: 4.939

Review 2.  Acute graft-versus-host disease: a bench-to-bedside update.

Authors:  Shernan G Holtan; Marcelo Pasquini; Daniel J Weisdorf
Journal:  Blood       Date:  2014-06-09       Impact factor: 22.113

3.  Transplantation of anergic histoincompatible bone marrow allografts.

Authors:  E C Guinan; V A Boussiotis; D Neuberg; L L Brennan; N Hirano; L M Nadler; J G Gribben
Journal:  N Engl J Med       Date:  1999-06-03       Impact factor: 91.245

4.  Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.

Authors:  E Williamson; P Garside; J A Bradley; I A More; A M Mowat
Journal:  J Immunol       Date:  1997-08-01       Impact factor: 5.422

5.  Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

Authors:  Nicola Gagliani; Chiara F Magnani; Samuel Huber; Monica E Gianolini; Mauro Pala; Paula Licona-Limon; Binggege Guo; De'Broski R Herbert; Alessandro Bulfone; Filippo Trentini; Clelia Di Serio; Rosa Bacchetta; Marco Andreani; Leonie Brockmann; Silvia Gregori; Richard A Flavell; Maria-Grazia Roncarolo
Journal:  Nat Med       Date:  2013-04-28       Impact factor: 53.440

6.  Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).

Authors:  Oliver C Goodyear; Mike Dennis; Nadira Y Jilani; Justin Loke; Shamyla Siddique; Gordon Ryan; Jane Nunnick; Rahela Khanum; Manoj Raghavan; Mark Cook; John A Snowden; Mike Griffiths; Nigel Russell; John Yin; Charles Crawley; Gordon Cook; Paresh Vyas; Paul Moss; Ram Malladi; Charles F Craddock
Journal:  Blood       Date:  2012-01-10       Impact factor: 22.113

7.  Plasma CXCL9 elevations correlate with chronic GVHD diagnosis.

Authors:  Carrie L Kitko; John E Levine; Barry E Storer; Xiaoyu Chai; David A Fox; Thomas M Braun; Daniel R Couriel; Paul J Martin; Mary E Flowers; John A Hansen; Lawrence Chang; Megan Conlon; Bryan J Fiema; Rachel Morgan; Prae Pongtornpipat; Kelly Lamiman; James L M Ferrara; Stephanie J Lee; Sophie Paczesny
Journal:  Blood       Date:  2013-12-20       Impact factor: 22.113

8.  An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.

Authors:  Madhav D Sharma; Lei Huang; Jeong-Hyeon Choi; Eun-Joon Lee; James M Wilson; Henrique Lemos; Fan Pan; Bruce R Blazar; Drew M Pardoll; Andrew L Mellor; Huidong Shi; David H Munn
Journal:  Immunity       Date:  2013-05-16       Impact factor: 31.745

9.  Early renal ischemia-reperfusion injury in humans is dominated by IL-6 release from the allograft.

Authors:  D K de Vries; J H N Lindeman; D Tsikas; E de Heer; A Roos; J W de Fijter; A G Baranski; J van Pelt; A F M Schaapherder
Journal:  Am J Transplant       Date:  2009-05-20       Impact factor: 8.086

10.  Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.

Authors:  Lisa K Jasperson; Christoph Bucher; Angela Panoskaltsis-Mortari; Andrew L Mellor; David H Munn; Bruce R Blazar
Journal:  Blood       Date:  2009-10-14       Impact factor: 22.113
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  49 in total

1.  C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

Authors:  Divya A Verghese; Nicholas Chun; Katelyn Paz; Miguel Fribourg; Trent M Woodruff; Ryan Flynn; Yuan Hu; Huabao Xiong; Weijia Zhang; Zhengzi Yi; Jing Du; Bruce R Blazar; Peter S Heeger
Journal:  JCI Insight       Date:  2018-12-20

2.  Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Authors:  Katelyn Paz; Ryan Flynn; Jing Du; Stacey Tannheimer; Amy J Johnson; Shuai Dong; Anne-Katrien Stark; Klaus Okkenhaug; Angela Panoskaltsis-Mortari; Peter T Sage; Arlene H Sharpe; Leo Luznik; Jerome Ritz; Robert J Soiffer; Corey S Cutler; John Koreth; Joseph H Antin; David B Miklos; Kelli P MacDonald; Geoffrey R Hill; Ivan Maillard; Jonathan S Serody; William J Murphy; David H Munn; Colby Feser; Michael Zaiken; Bart Vanhaesebroeck; Laurence A Turka; John C Byrd; Bruce R Blazar
Journal:  Am J Transplant       Date:  2019-03-19       Impact factor: 8.086

3.  Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks.

Authors:  Mohamed B Ezzelarab; Angus W Thomson
Journal:  Curr Transplant Rep       Date:  2016-10-25

4.  Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Authors:  Jooho Chung; Christen L Ebens; Eric Perkey; Vedran Radojcic; Ute Koch; Leonardo Scarpellino; Alexander Tong; Frederick Allen; Sherri Wood; Jiane Feng; Ann Friedman; David Granadier; Ivy T Tran; Qian Chai; Lucas Onder; Minhong Yan; Pavan Reddy; Bruce R Blazar; Alex Y Huang; Todd V Brennan; D Keith Bishop; Burkhard Ludewig; Christian W Siebel; Freddy Radtke; Sanjiv A Luther; Ivan Maillard
Journal:  J Clin Invest       Date:  2017-03-20       Impact factor: 14.808

Review 5.  Graft Versus Host Disease After Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management.

Authors:  Arvind R Murali; Subhash Chandra; Zoe Stewart; Bruce R Blazar; Umar Farooq; M Nedim Ince; Jeffrey Dunkelberg
Journal:  Transplantation       Date:  2016-12       Impact factor: 4.939

6.  Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts.

Authors:  Heng Xu; Satinder Dahiya; Liqing Wang; Tatiana Akimova; Rongxiang Han; Tianyi Zhang; Yixin Zhang; Ling Qin; Matthew H Levine; Wayne W Hancock; L Scott Levin
Journal:  Transplantation       Date:  2018-01       Impact factor: 4.939

7.  Preserved Liver Transplant After PD-1 Pathway Inhibitor for Hepatocellular Carcinoma.

Authors:  Andreas Varkaris; David W Lewis; Francis W Nugent
Journal:  Am J Gastroenterol       Date:  2017-12       Impact factor: 10.864

8.  Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.

Authors:  Scott N Furlan; Benjamin Watkins; Victor Tkachev; Sarah Cooley; Angela Panoskaltsis-Mortari; Kayla Betz; Melanie Brown; Daniel J Hunt; John B Schell; Katie Zeleski; Alison Yu; Cynthia R Giver; Edmund K Waller; Jeffrey S Miller; Bruce R Blazar; Leslie S Kean
Journal:  Blood       Date:  2016-10-06       Impact factor: 22.113

Review 9.  Chronic graft-versus-host disease: biological insights from preclinical and clinical studies.

Authors:  Kelli P A MacDonald; Geoffrey R Hill; Bruce R Blazar
Journal:  Blood       Date:  2016-11-07       Impact factor: 22.113

10.  High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation.

Authors:  Karine Robitaille; Jillian L Rourke; Joanne E McBane; Accalia Fu; Stephen Baird; Qiujiang Du; Tatsuya Kin; A M James Shapiro; Robert A Screaton
Journal:  J Biol Chem       Date:  2016-01-06       Impact factor: 5.157
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