Ole Birger Pedersen1, Skytthe Axel2, Klaus Rostgaard3, Christian Erikstrup4, Gustaf Edgren5, Kaspar René Nielsen6, Henrik Ullum7, Kirsten Ohm Kyvik8, Henrik Hjalgrim3. 1. Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark. 2. Danish Twin Registry, University of Southern Denmark, Odense, Denmark. 3. Department of Epidemiology Research, Statens Serum Institut. 4. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 5. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden. 6. Department of Clinical Immunology, Aalborg Hospital, Aalborg, Denmark. 7. Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark. 8. Institute of Regional Health Research, University of Southern Denmark and Odense Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Abstract
BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins. STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model. RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56-0.67) and 0.41 (95% CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33-0.73) and 0.28 (95% CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively. CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.
BACKGROUND: Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins. STUDY DESIGN AND METHODS: The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model. RESULTS: A total of 274 MZ and 484 same-sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56-0.67) and 0.41 (95% CI, 0.36-0.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33-0.73) and 0.28 (95% CI, 0.10-0.45) of the variance in the motivation to donate blood, respectively. CONCLUSION: Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.
Authors: Tjeerd W Piersma; René Bekkers; Elisabeth F Klinkenberg; Wim L A M De Kort; Eva-Maria Merz Journal: Blood Transfus Date: 2017-06-13 Impact factor: 3.443
Authors: Matthew S Karafin; Roberta Bruhn; Matt Westlake; Marian T Sullivan; Walter Bialkowski; Gustaf Edgren; Nareg H Roubinian; Ronald G Hauser; Daryl J Kor; Debra Fleischmann; Jerome L Gottschall; Edward L Murphy; Darrell J Triulzi Journal: Transfusion Date: 2017-10-24 Impact factor: 3.157
Authors: Thomas Folkmann Hansen; Karina Banasik; Christian Erikstrup; Ole Birger Pedersen; David Westergaard; Piotr Jaroslaw Chmura; Kaspar Nielsen; Lise Thørner; Henrik Hjalgrim; Helene Paarup; Margit Anita Hørup Larsen; Mikkel Petersen; Poul Jennum; Steffen Andersen; Mette Nyegaard; Gregor Borut Ernst Jemec; Jes Olesen; Thomas Werge; Pär I Johansson; Erik Sørensen; Søren Brunak; Henrik Ullum; Kristoffer Sølvsten Burgdorf Journal: BMJ Open Date: 2019-06-09 Impact factor: 2.692