Yan Sun1, Yue Yuan2, Hui Yan1, Hong Wan1, Xueying Li3, Siyao Chen1, Hongxia Li1, Chaoshu Tang4, Junbao Du1,5, Guiying Liu6, Hongfang Jin1. 1. Department of Pediatrics, Peking University First Hospital. 2. Department of Pediatric Cardiology, Beijing Children's Hospital. 3. Department of Medical Statistics, Peking University First Hospital. 4. Department of Physiology and Pathophysiology, Peking University Health Science Center. 5. Key Laboratory of Molecular Cardiology, Ministry of Education. 6. Department of Pediatrics, Beijing Anzhen Hospital, Beijing, China.
Abstract
BACKGROUND: The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD). METHODS: A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out. RESULTS: Plasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children. CONCLUSION: Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.
BACKGROUND: The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD). METHODS: A prospective study was conducted on 50 KDpatients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out. RESULTS: Plasma H2S in KDpatients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KDchildren. CONCLUSION: Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KDchildren.