Literature DB >> 25807941

MicroRNA Therapeutics: the Next Magic Bullet?

Bridget Simonson, Saumya Das1.   

Abstract

MicroRNAs are short noncoding 18-25 nucleotide long RNA which bind and inhibit mRNA. Currently, there are over 1000 known human microRNAs, and microRNAs control over 50% of mammalian protein coding genes. MicroRNAs can be overexpressed or repressed in different diseases and inhibition or replacement of microRNAs is a promising area of study for therapeutics. Here we review the current knowledge of microRNA therapy, and discuss ways in which they can be utilized. We also discuss different methods of delivery of miRNA, and current clinical trials of microRNA-based therapies for disease. Finally we discuss the current limitations in the field, and how these limitations are being overcome.

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Year:  2015        PMID： 25807941      PMCID： PMC4410078          DOI： 10.2174/1389557515666150324123208

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  63 in total

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Authors:  G Hutvágner; J McLachlan; A E Pasquinelli; E Bálint; T Tuschl; P D Zamore
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Review 2.  Magnetic nanoparticles and targeted drug delivering.

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Journal:  Pharmacol Res       Date:  2010-02-10       Impact factor: 7.658

3.  A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo.

Authors:  Luyue Chen; Kailiang Zhang; Zhendong Shi; Anling Zhang; Zhifan Jia; Guangxiu Wang; Peiyu Pu; Chunsheng Kang; Lei Han
Journal:  Oncol Rep       Date:  2014-02-04       Impact factor: 3.906

4.  Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34.

Authors:  Jason F Wiggins; Lynnsie Ruffino; Kevin Kelnar; Michael Omotola; Lubna Patrawala; David Brown; Andreas G Bader
Journal:  Cancer Res       Date:  2010-06-22       Impact factor: 12.701

5.  MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma.

Authors:  Ahmed Fawzy Ibrahim; Ulrike Weirauch; Maren Thomas; Arnold Grünweller; Roland K Hartmann; Achim Aigner
Journal:  Cancer Res       Date:  2011-06-20       Impact factor: 12.701

Review 6.  Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.

Authors:  Michelle Longmire; Peter L Choyke; Hisataka Kobayashi
Journal:  Nanomedicine (Lond)       Date:  2008-10       Impact factor: 5.307

7.  Targeting miR-21 for the therapy of pancreatic cancer.

Authors:  Flavie Sicard; Marion Gayral; Hubert Lulka; Louis Buscail; Pierre Cordelier
Journal:  Mol Ther       Date:  2013-03-12       Impact factor: 11.454

8.  Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

Authors:  Lawrence T Bish; Kevin Morine; Meg M Sleeper; Julio Sanmiguel; Di Wu; Guangping Gao; James M Wilson; H Lee Sweeney
Journal:  Hum Gene Ther       Date:  2008-12       Impact factor: 5.695

9.  Liposomes for use in gene delivery.

Authors:  Daniel A Balazs; Wt Godbey
Journal:  J Drug Deliv       Date:  2010-12-15

10.  Inhibition of miR-25 improves cardiac contractility in the failing heart.

Authors:  Christine Wahlquist; Dongtak Jeong; Agustin Rojas-Muñoz; Changwon Kho; Ahyoung Lee; Shinichi Mitsuyama; Alain van Mil; Woo Jin Park; Joost P G Sluijter; Pieter A F Doevendans; Roger J Hajjar; Mark Mercola
Journal:  Nature       Date:  2014-03-12       Impact factor: 49.962
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  80 in total

1.  Bioinformatically-predicted varicella zoster virus small non-coding RNAs are expressed in lytically-infected epithelial cells and neurons.

Authors:  Linoy Golani-Zaidie; Tatiana Borodianskiy-Shteinberg; Punam Bisht; Biswajit Das; Paul R Kinchington; Ronald S Goldstein
Journal:  Virus Res       Date:  2019-10-12       Impact factor: 3.303

Review 2.  miRNA signatures in childhood sarcomas and their clinical implications.

Authors:  G M Viera; K B Salomao; G R de Sousa; M Baroni; L E A Delsin; J A Pezuk; M S Brassesco
Journal:  Clin Transl Oncol       Date:  2019-04-04       Impact factor: 3.405

3.  MiR-214-3p regulates the viability, invasion, migration and EMT of TNBC cells by targeting ST6GAL1.

Authors:  Yun Tao; Zhijing Zhao; Junfeng Ma; Liying Dong; Ying Liang; Siqi Li; Ying Mao; Yan Li; Yi Zhang
Journal:  Cytotechnology       Date:  2019-11-08       Impact factor: 2.058

Review 4.  Cerebral Amyloid Angiopathy, Alzheimer's Disease and MicroRNA: miRNA as Diagnostic Biomarkers and Potential Therapeutic Targets.

Authors:  J Weldon Furr; Diego Morales-Scheihing; Bharti Manwani; Juneyoung Lee; Louise D McCullough
Journal:  Neuromolecular Med       Date:  2019-10-04       Impact factor: 3.843

Review 5.  MicroRNAs as Master Regulators of Glomerular Function in Health and Disease.

Authors:  Piera Trionfini; Ariela Benigni
Journal:  J Am Soc Nephrol       Date:  2017-02-23       Impact factor: 10.121

6.  Technological advances in precision medicine and drug development.

Authors:  Elaine Maggi; Nicole E Patterson; Cristina Montagna
Journal:  Expert Rev Precis Med Drug Dev       Date:  2016-05-05

Review 7.  MicroRNAs in laryngeal cancer: implications for diagnosis, prognosis and therapy.

Authors:  Pei Li; Hui Liu; Zhiyuan Wang; Feng He; Haifeng Wang; Zhi Shi; Ankui Yang; Jin Ye
Journal:  Am J Transl Res       Date:  2016-05-15       Impact factor: 4.060

8.  miR-211 promotes lens epithelial cells apoptosis by targeting silent mating-type information regulation 2 homolog 1 in age-related cataracts.

Authors:  Bo Lu; Ian T Christensen; Li-Wei Ma; Xin-Ling Wang; Ling-Feng Jiang; Chun-Xia Wang; Li Feng; Jin-Song Zhang; Qi-Chang Yan
Journal:  Int J Ophthalmol       Date:  2018-02-18       Impact factor: 1.779

Review 9.  MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives.

Authors:  Audrey McAlinden; Gun-Il Im
Journal:  J Orthop Res       Date:  2017-12-19       Impact factor: 3.494

10.  Overexpression of MicroRNA-221 is associated with poor prognosis in non-small cell lung cancer patients.

Authors:  Yahui Zhang; Yanpeng Zhao; Shengjie Sun; Zhefeng Liu; Yixin Zhang; Shunchang Jiao
Journal:  Tumour Biol       Date:  2016-01-29
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