| Literature DB >> 25807283 |
Stacy Steinberg1, Hreinn Stefansson1, Thorlakur Jonsson1, Hrefna Johannsdottir1, Andres Ingason1, Hannes Helgason1, Patrick Sulem1, Olafur Th Magnusson1, Sigurjon A Gudjonsson1, Unnur Unnsteinsdottir1, Augustine Kong1, Seppo Helisalmi2, Hilkka Soininen2, James J Lah3, Dag Aarsland4, Tormod Fladby5, Ingun D Ulstein6, Srdjan Djurovic7, Sigrid B Sando8, Linda R White8, Gun-Peggy Knudsen9, Lars T Westlye10, Geir Selbæk11, Ina Giegling12, Harald Hampel13, Mikko Hiltunen14, Allan I Levey3, Ole A Andreassen15, Dan Rujescu12, Palmi V Jonsson16, Sigurbjorn Bjornsson17, Jon Snaedal17, Kari Stefansson18.
Abstract
We conducted a search for rare, functional variants altering susceptibility to Alzheimer's disease that exploited knowledge of common variants associated with the same disease. We found that loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12, P = 2.2 × 10(-13)) and discovered that the association replicated in study groups from Europe and the United States (combined OR = 2.03, P = 6.8 × 10(-15)).Entities:
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Year: 2015 PMID： 25807283 DOI： 10.1038/ng.3246
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330