Christopher Welsh1, Jingyi Pan1, Jaques Belik2. 1. Physiology & Experimental Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada. 2. 1] Physiology & Experimental Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada [2] Department of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, Canada.
Abstract
BACKGROUND: Feeding intolerance is commonly documented in premature infants. Caffeine is routinely utilized for apnea of prematurity treatment and known to reduce the lower esophageal sphincter (LES) muscle tone, but the caffeine effect on the newborn gastrointestinal function is unknown. We hypothesized that caffeine impairs esophageal and gastrointestinal motor function. As such, we investigated the drug effect on the tissue's mechanical properties and the newborn rat's in vivo gastric emptying rate. METHODS: The effects of caffeine on LES, gastric fundal and antrum, as well as ileal and colonic muscle force potential and relaxation response, were measured in newborn and adult rats. The caffeine-induced (10 mg/kg i.p.) newborn gastric emptying rate changes were evaluated following 3 h of fasting. RESULTS: Caffeine relaxed the precontracted LES and fundal muscle (P < 0.01), reduced the gastric and intestinal muscle contraction (P < 0.01), and delayed the pups' gastric emptying time (P < 0.01). The caffeine-induced muscle relaxant effect was independent of age and mediated via ryanodine receptors. CONCLUSION: Caffeine administration to newborn rats at a dose comparable to the one therapeutically used for preterm neonates impairs LES and gastrointestinal motor function. Further clinical investigation on the possible contribution of caffeine to neonatal feeding intolerance is warranted.
BACKGROUND: Feeding intolerance is commonly documented in premature infants. Caffeine is routinely utilized for apnea of prematurity treatment and known to reduce the lower esophageal sphincter (LES) muscle tone, but the caffeine effect on the newborn gastrointestinal function is unknown. We hypothesized that caffeineimpairs esophageal and gastrointestinal motor function. As such, we investigated the drug effect on the tissue's mechanical properties and the newborn rat's in vivo gastric emptying rate. METHODS: The effects of caffeine on LES, gastric fundal and antrum, as well as ileal and colonic muscle force potential and relaxation response, were measured in newborn and adult rats. The caffeine-induced (10 mg/kg i.p.) newborn gastric emptying rate changes were evaluated following 3 h of fasting. RESULTS:Caffeine relaxed the precontracted LES and fundal muscle (P < 0.01), reduced the gastric and intestinal muscle contraction (P < 0.01), and delayed the pups' gastric emptying time (P < 0.01). The caffeine-induced muscle relaxant effect was independent of age and mediated via ryanodine receptors. CONCLUSION:Caffeine administration to newborn rats at a dose comparable to the one therapeutically used for preterm neonates impairs LES and gastrointestinal motor function. Further clinical investigation on the possible contribution of caffeine to neonatal feeding intolerance is warranted.
Authors: A Gounaris; P Kokori; L Varchalama; K Konstandinidi; M Skouroliakou; N Alexiou; C Costalos Journal: Arch Dis Child Fetal Neonatal Ed Date: 2004-07 Impact factor: 5.747
Authors: Wanessa Costa Silva Faria; Alessandra Almeida da Silva; Natalie Veggi; Nair Honda Kawashita; Suelem A de França Lemes; Wander Miguel de Barros; Edemilson da Conceição Cardoso; Attilio Converti; Waldênia de Melo Moura; Neura Bragagnolo Journal: J Food Drug Anal Date: 2020-06-15 Impact factor: 6.157
Authors: Luciano N de Sousa; Débora S Paraguassú Sant'ana; Rildo G Siqueira Dos Santos; Anita Eugênia A Dos Santos Ribeiro; Camila F da Costa; Ana Paula de Oliveira; Jackson Roberto G da Silva Almeida; Davi M Jucá; Moisés Tolentino; Armênio A Dos Santos; Raimundo C Palheta Junior Journal: Curr Res Pharmacol Drug Discov Date: 2021-02-05