Literature DB >> 25806270

The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma.

Timothy G Whitsett1, Landon J Inge2, Nhan L Tran1.   

Abstract

The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.

Entities:  

Keywords:  Lung squamous cell carcinoma; glutathione s-transferase pi 1 (GSTP1); isobaric tags for relative and absolute quantitation (iTRAQ); proteomics

Year:  2013        PMID： 25806270      PMCID： PMC4367630          DOI： 10.3978/j.issn.2218-6751.2013.10.17

Source DB:  PubMed          Journal:  Transl Lung Cancer Res        ISSN： 2218-6751


  20 in total

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Authors:  Rebecca S Heist; Jeffrey A Engelman
Journal:  Cancer Cell       Date:  2012-03-20       Impact factor: 31.743

2.  Evaluation of carcinoembryonic antigen (CEA) and brain-type creatine kinase (CK-BB) in serum from patients with carcinoma of the lung.

Authors:  J Nikliński; M Furman; J Laudański; Z Pałynyczko; M Welk
Journal:  Neoplasma       Date:  1991       Impact factor: 2.575

3.  Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer.

Authors:  Yan-Sheng Liu; Xiao-Yang Luo; Qing-Run Li; Hong Li; Chen Li; Hong Ni; Rong-Xia Li; Rui Wang; Hai-Chuan Hu; Yun-Jian Pan; Hai-Quan Chen; Rong Zeng
Journal:  J Mol Cell Biol       Date:  2012-10       Impact factor: 6.216

4.  Identification of candidate biomarkers for early detection of human lung squamous cell cancer by quantitative proteomics.

Authors:  Gu-Qing Zeng; Pang-Fei Zhang; Xingming Deng; Feng-Lei Yu; Cui Li; Yan Xu; Hong Yi; Mao-Yu Li; Rong Hu; Jian-Hong Zuo; Xin-Hui Li; Xun-Xun Wan; Jia-Quan Qu; Qiu-Yan He; Jian-Huang Li; Xu Ye; Yu Chen; Jiao-Yang Li; Zhi-Qiang Xiao
Journal:  Mol Cell Proteomics       Date:  2012-01-31       Impact factor: 5.911

Review 5.  Advances in proteomic strategies toward the early detection of lung cancer.

Authors:  Mohamed Hassanein; Jamshedur S M Rahman; Pierre Chaurand; Pierre P Massion
Journal:  Proc Am Thorac Soc       Date:  2011-05

6.  Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma.

Authors:  K Ozerkan; M A Atalay; T Yakut; Y Doster; E Yilmaz; M Karkucak
Journal:  Eur J Gynaecol Oncol       Date:  2013       Impact factor: 0.196

7.  MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.

Authors:  Ning Sun; Xinchen Sun; Baoan Chen; Hongyan Cheng; Jifeng Feng; Lu Cheng; Zuhong Lu
Journal:  Cancer Chemother Pharmacol       Date:  2009-07-01       Impact factor: 3.333

Review 8.  Lung cancer preneoplasia.

Authors:  Ignacio I Wistuba; Adi F Gazdar
Journal:  Annu Rev Pathol       Date:  2006       Impact factor: 23.472

Review 9.  Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review.

Authors:  D R Ciocca; S Oesterreich; G C Chamness; W L McGuire; S A Fuqua
Journal:  J Natl Cancer Inst       Date:  1993-10-06       Impact factor: 13.506

10.  Identification of proteomic signatures associated with lung cancer and COPD.

Authors:  M D Pastor; A Nogal; S Molina-Pinelo; R Meléndez; A Salinas; M González De la Peña; J Martín-Juan; J Corral; R García-Carbonero; A Carnero; L Paz-Ares
Journal:  J Proteomics       Date:  2013-05-09       Impact factor: 4.044
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