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Literature DB >> 2580570

Voltage-dependent removal of sodium inactivation by N-bromoacetamide and pronase.

Abstract

When perfused internally through crayfish giant axons, pronase removed sodium inactivation more than three times as fast at -100 mV as compared with -30 mV. N-bromoacetamide, applied internally, removed sodium inactivation twice as fast at -100 mV as at -30 mV, and the relative rate of removal declined with membrane depolarization in proportion to steady-state sodium inactivation. We conclude that in the closed conformation the sodium inactivation gate is partially protected from destruction by N-bromoacetamide and pronase.

Entities: Chemical

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Year: 1985 PMID： 2580570 PMCID： PMC1435119 DOI： 10.1016/S0006-3495(85)83952-7

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

11 in total

7. Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability.

Authors: E C Cooper; S A Tomiko; W S Agnew
Journal: Proc Natl Acad Sci U S A Date: 1987-09 Impact factor: 11.205

8. Removal of rapid sensory adaptation from an insect mechanoreceptor neuron by oxidizing agents which affect sodium channel inactivation.

Authors: A S French
Journal: J Comp Physiol A Date: 1987-08 Impact factor: 1.836

9. The inactivating K+ current in GH3 pituitary cells and its modification by chemical reagents.

Authors: G S Oxford; P K Wagoner
Journal: J Physiol Date: 1989-03 Impact factor: 5.182

10. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide.

Authors: E C Cooper; W S Agnew
Journal: J Membr Biol Date: 1989-11 Impact factor: 1.843

Voltage-dependent removal of sodium inactivation by N-bromoacetamide and pronase.

1. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

2. Modification of sodium channel kinetics by the insecticide tetramethrin in crayfish giant axons.

3. Gating charge immobilization and sodium current inactivation in internally perfused crayfish axons.

4. Modification of slow sodium inactivation in nerve after internal perfusion with trypsin.

5. Removal of sodium channel inactivation in squid giant axons by n-bromoacetamide.

6. Destruction of the sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo.

7. Some kinetic and steady-state properties of sodium channels after removal of inactivation.

8. Current-voltage relations in the lobster giant axon membrane under voltage clamp conditions.

9. Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique.

10. Destruction of sodium conductance inactivation in squid axons perfused with pronase.

1. A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation.

2. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels.

3. Effects of laser-induced hyperthermia treatment on ionic permeability of myelinated nerve.

4. A simple hanging-drop patch-clamp technique for studying single channel activities in excised membrane patches.

5. Interaction between fast and slow inactivation in Skm1 sodium channels.

6. Inhibition of inactivation of single sodium channels by a site-directed antibody.

7. Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability.

8. Removal of rapid sensory adaptation from an insect mechanoreceptor neuron by oxidizing agents which affect sodium channel inactivation.

9. The inactivating K+ current in GH3 pituitary cells and its modification by chemical reagents.

10. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide.