Nicole Gordon1, Gordon Riha2, Kevin Billingsley3, Martin Schreiber4. 1. Division of Trauma, Critical Care and Acute Care Surgery, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA. Electronic address: gordonni@ohsu.edu. 2. Billings Clinic, 801 North 29th Street, Billings, MT, USA. 3. Division of Surgical Oncology, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA. 4. Division of Trauma, Critical Care and Acute Care Surgery, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA.
Abstract
BACKGROUND: A hypercoagulable state following intra-abdominal malignant resections has been reported. Whether this is because of the operation or the malignancy, a known cause of hypercoagulability, remains unclear. We determined if malignancy status affected the coagulation profile following liver resection by assessing perioperative thromboelastogram (TEG) values. METHODS: Retrospective review of prospectively collected TEG values in patients who received a liver resection was conducted. Values among patients with benign or malignant disease were compared. RESULTS: Fourteen and 63 patients were resected for benign and malignant disease, respectively. No significant differences in TEG values existed between the groups. Combining the groups, patients developed a relative hypercoagulable state postoperatively with decreased R-times (P < .05), although median values remained within the normal range. CONCLUSION: Following liver resection, no differences in TEG values existed between patients with benign and malignant disease; the relative hypercoagulable state is more likely driven by postoperative coagulopathy rather than the malignancy status of the patient.
BACKGROUND: A hypercoagulable state following intra-abdominal malignant resections has been reported. Whether this is because of the operation or the malignancy, a known cause of hypercoagulability, remains unclear. We determined if malignancy status affected the coagulation profile following liver resection by assessing perioperative thromboelastogram (TEG) values. METHODS: Retrospective review of prospectively collected TEG values in patients who received a liver resection was conducted. Values among patients with benign or malignant disease were compared. RESULTS: Fourteen and 63 patients were resected for benign and malignant disease, respectively. No significant differences in TEG values existed between the groups. Combining the groups, patients developed a relative hypercoagulable state postoperatively with decreased R-times (P < .05), although median values remained within the normal range. CONCLUSION: Following liver resection, no differences in TEG values existed between patients with benign and malignant disease; the relative hypercoagulable state is more likely driven by postoperative coagulopathy rather than the malignancy status of the patient.
Authors: Hongji Zhang; Julie Goswami; Patrick Varley; Dirk J van der Windt; Jinghua Ren; Patricia Loughran; Hamza Yazdani; Matthew D Neal; Richard L Simmons; Jinxiang Zhang; Allan Tsung; Hai Huang Journal: Front Immunol Date: 2020-05-22 Impact factor: 7.561