Literature DB >> 2580525

Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells.

J S Flier, A C Moses.   

Abstract

A mouse monoclonal antibody directed against the human placental IGF-I receptor is shown to completely inhibit IGF-I binding to both human placental membranes and circulating human mononuclear leukocytes. Insulin binding is unaffected. Studies with 125I-labelled anti-receptor antibody indicate that the antibody reacts with an epitope distinct from the IGF-I binding site. These antibodies will be powerful probes of IGF-I binding and action in human cells.

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Year:  1985        PMID： 2580525     DOI： 10.1016/s0006-291x(85)80033-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

Review 1.  The insulin-like growth factor family of ligands, receptors, and binding proteins.

Authors:  R F Krywicki; D Yee
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

2.  Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

Authors:  J S Flier; P Usher; A C Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

3.  An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors.

Authors:  H A Jonas; J D Newman; L C Harrison
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

4.  Endogenous insulin-like growth factor (IGF) binding proteins cause IGF-1 resistance in cultured fibroblasts from a patient with short stature.

Authors:  S E Tollefsen; E Heath-Monnig; M A Cascieri; M L Bayne; W H Daughaday
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

5.  The receptor for insulin-like growth factor II mediates an insulin-like response.

Authors:  J Hari; S B Pierce; D O Morgan; V Sara; M C Smith; R A Roth
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598
  5 in total

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