BACKGROUND: Multifocality and multicentricity are increasingly recognized in breast cancer. However, little is known about the characteristics and biology of these cancers and the clinical implications are controversial. METHODS: A retrospective, institutional database was used to compare characteristics of multifocal (MF) and multicentric (MC) breast cancers with unifocal (UF) cancers to study concordance of histology and receptor status among primary and secondary foci and to evaluate predictors of lymph node positivity using multivariate logistic regression. RESULTS: Of 1495 invasive cancers, 1231 (82.3 %) were UF, 169 (11.3 %) were MF, and 95 (6.4 %) were MC cancers. When MF and MC cancers were compared with UF cancers, MC but not MF cancers were associated with young age at diagnosis, larger tumor size, lymphovascular invasion, and node positivity. MF but not MC tumors were more likely to be ER/PR+Her2+ tumors and less likely to be triple-negative cancers compared with UF tumors. MF tumors were more likely to be infiltrating ductal carcinomas with an extensive intraductal component, and MC tumors were more likely to be infiltrating lobular carcinomas. Concordance of histology and receptor status between primary and secondary foci was high and was similar for both MF and MC cancers. Multicentricity remained an independent predictor of lymph node positivity on multivariate analysis. CONCLUSION: MF and MC tumors seem to be biologically different diseases. MC is clinicopathologically more aggressive than MF disease and is more frequently associated with younger age and larger tumor size and also is an independent predictor of node positivity.
BACKGROUND: Multifocality and multicentricity are increasingly recognized in breast cancer. However, little is known about the characteristics and biology of these cancers and the clinical implications are controversial. METHODS: A retrospective, institutional database was used to compare characteristics of multifocal (MF) and multicentric (MC) breast cancers with unifocal (UF) cancers to study concordance of histology and receptor status among primary and secondary foci and to evaluate predictors of lymph node positivity using multivariate logistic regression. RESULTS: Of 1495 invasive cancers, 1231 (82.3 %) were UF, 169 (11.3 %) were MF, and 95 (6.4 %) were MCcancers. When MF and MCcancers were compared with UF cancers, MC but not MF cancers were associated with young age at diagnosis, larger tumor size, lymphovascular invasion, and node positivity. MF but not MCtumors were more likely to be ER/PR+Her2+ tumors and less likely to be triple-negative cancers compared with UF tumors. MF tumors were more likely to be infiltrating ductal carcinomas with an extensive intraductal component, and MCtumors were more likely to be infiltrating lobular carcinomas. Concordance of histology and receptor status between primary and secondary foci was high and was similar for both MF and MCcancers. Multicentricity remained an independent predictor of lymph node positivity on multivariate analysis. CONCLUSION: MF and MCtumors seem to be biologically different diseases. MC is clinicopathologically more aggressive than MF disease and is more frequently associated with younger age and larger tumor size and also is an independent predictor of node positivity.
Authors: Ellen L Nutter; Julia E Weiss; Jonathan D Marotti; Richard J Barth; M Scottie Eliassen; Martha E Goodrich; Curtis L Petersen; Tracy Onega Journal: Cancer Date: 2017-12-20 Impact factor: 6.860
Authors: Alan D McCrorie; Susannah Ashfield; Aislinn Begley; Colin Mcilmunn; Patrick J Morrison; Clinton Boyd; Bryony Eccles; Stephanie Greville-Heygate; Ellen R Copson; Ramsey I Cutress; Diana M Eccles; Kienan I Savage; Stuart A McIntosh Journal: J Pathol Clin Res Date: 2020-02-05
Authors: Lobna Ouldamer; Caroline Goupille; Anne Vildé; Flavie Arbion; Gilles Body; Stephan Chevalier; Jean Philippe Cottier; Philippe Bougnoux Journal: PLoS One Date: 2016-01-26 Impact factor: 3.240