Literature DB >> 25804720

Identification and characterization of β-sitosterol target proteins.

Brett Lomenick1, Heping Shi2, Jing Huang3, Chuo Chen4.   

Abstract

β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  17β-HSD4; E-Syt1; Phytosterol; Target identification; β-Sitosterol

Mesh：

Substances：

Year:  2015        PMID： 25804720      PMCID： PMC4567552          DOI： 10.1016/j.bmcl.2015.03.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  38 in total

1.  Effect of beta-sitosterol as inhibitor of 5 alpha-reductase in hamster prostate.

Authors:  Marisa Cabeza; Eugene Bratoeff; Ivonne Heuze; Elena Ramírez; Mauricio Sánchez; Eugenio Flores
Journal:  Proc West Pharmacol Soc       Date:  2003

2.  Characterizing components of the Saw Palmetto Berry Extract (SPBE) on prostate cancer cell growth and traction.

Authors:  Carina Scholtysek; Aleksandra A Krukiewicz; José-Luis Alonso; Karan P Sharma; Pal C Sharma; Wolfgang H Goldmann
Journal:  Biochem Biophys Res Commun       Date:  2008-12-06       Impact factor: 3.575

3.  Anti-inflammatory and antipyretic activities of beta-sitosterol.

Authors:  M B Gupta; R Nath; N Srivastava; K Shanker; K Kishor; K P Bhargava
Journal:  Planta Med       Date:  1980-06       Impact factor: 3.352

Review 4.  Phytosterols as anticancer dietary components: evidence and mechanism of action.

Authors:  A B Awad; C S Fink
Journal:  J Nutr       Date:  2000-09       Impact factor: 4.798

Review 5.  Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses.

Authors:  Robert A Moreau; Bruce D Whitaker; Kevin B Hicks
Journal:  Prog Lipid Res       Date:  2002-11       Impact factor: 16.195

6.  Bioactivity studies on beta-sitosterol and its glucoside.

Authors:  Irene M Villaseñor; Jennifer Angelada; Arlyn P Canlas; Deborah Echegoyen
Journal:  Phytother Res       Date:  2002-08       Impact factor: 5.878

7.  Sterol content of foods of plant origin.

Authors:  J L Weihrauch; J M Gardner
Journal:  J Am Diet Assoc       Date:  1978-07

8.  Beta-sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis.

Authors:  Cheol Park; Dong-oh Moon; Chung-ho Ryu; Byung tae Choi; Won ho Lee; Gi-young Kim; Yung hyun Choi
Journal:  Acta Pharmacol Sin       Date:  2008-03       Impact factor: 6.150

Review 9.  Phytosterols in human nutrition.

Authors:  Richard E Ostlund
Journal:  Annu Rev Nutr       Date:  2002-04-04       Impact factor: 11.848

10.  Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer.

Authors:  Shan Zha; Sacha Ferdinandusse; Simone Denis; Ronald J Wanders; Charles M Ewing; Jun Luo; Angelo M De Marzo; William B Isaacs
Journal:  Cancer Res       Date:  2003-11-01       Impact factor: 12.701
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  2 in total

Review 1.  Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol.

Authors:  Muhammad Shahdaat Bin Sayeed; Selim Muhammad Rezaul Karim; Tasnuva Sharmin; Mohammed Monzur Morshed
Journal:  Medicines (Basel)       Date:  2016-11-15

2.  Metabolomics and physiological analyses reveal β-sitosterol as an important plant growth regulator inducing tolerance to water stress in white clover.

Authors:  Zhou Li; Bizhen Cheng; Bin Yong; Ting Liu; Yan Peng; Xinquan Zhang; Xiao Ma; Linkai Huang; Wei Liu; Gang Nie
Journal:  Planta       Date:  2019-09-21       Impact factor: 4.116
  2 in total

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