Literature DB >> 2580348

The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity.

C W Rettenmier, J H Chen, M F Roussel, C J Sherr.   

Abstract

The c-fms proto-oncogene is a member of a gene family that has been implicated in tumorigenesis. Glycoproteins encoded by c-fms were identified in cat spleen cells by means of an immune-complex kinase assay performed with monoclonal antibodies to v-fms-coded epitopes. The major form of the normal cellular glycoprotein has an apparent molecular weight of 170,000 and, like the product of the viral oncogene, serves as a substrate for an associated tyrosine-specific protein kinase activity in vitro. The results suggest that the transforming glycoprotein specified by v-fms is a truncated form of a c-fms-coded growth factor receptor.

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Year:  1985        PMID： 2580348     DOI： 10.1126/science.2580348

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  45 in total

1.  Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.

Authors:  J Visvader; I M Verma
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

2.  CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor.

Authors:  Gary Glenn; Peter van der Geer
Journal:  FEBS Lett       Date:  2007-10-29       Impact factor: 4.124

Review 3.  Structure and function of tyrosine kinase receptors.

Authors:  M F White
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

4.  c-kit protein, a transmembrane kinase: identification in tissues and characterization.

Authors:  S Majumder; K Brown; F H Qiu; P Besmer
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

5.  A recessive cellular mutation in v-fes-transformed mink cells restores contact inhibition and anchorage-dependent growth.

Authors:  J R Haynes; J R Downing
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

6.  The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

Authors:  E N Olson; G Spizz; M A Tainsky
Journal:  Mol Cell Biol       Date:  1987-06       Impact factor: 4.272

7.  Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor.

Authors:  M F Roussel; C J Sherr
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

8.  The human c-ros gene (ROS) is located at chromosome region 6q16----6q22.

Authors:  L Nagarajan; E Louie; Y Tsujimoto; P C Balduzzi; K Huebner; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

9.  Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells.

Authors:  C Walker; P Nettesheim; J C Barrett; T M Gilmer
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

10.  Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1.

Authors:  X X Xu; T G Tessner; C O Rock; S Jackowski
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272
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