BACKGROUND: Non-muscle-invasive bladder cancer with a low-grade differentiation represents a special challenge. METHOD: Although urine cytology is still the most reliable and effective urine-based marker and there are no substantial novel aspects in this field, photodynamic diagnostics have the most important value in transurethral resection of the bladder (TURB) of high-grade T1 tumors and new techniques, such as hybrid knife TURB are coming up. The histopathological assessment of T1 tumors can be supplemented by a description of the exact penetration depth, so-called substaging and the invasion pattern. RESULTS: Intravesicle therapy with Bacillus Calmette-Guèrin (BCG) represents the gold standard and a pillar of bladder-preserving therapy and should be planned as maintenance therapy for at least 1 year. With the right risk constellation cystectomy is a safe and proven concept for high-grade bladder cancer, even without proof of muscle invasion.
BACKGROUND: Non-muscle-invasive bladder cancer with a low-grade differentiation represents a special challenge. METHOD: Although urine cytology is still the most reliable and effective urine-based marker and there are no substantial novel aspects in this field, photodynamic diagnostics have the most important value in transurethral resection of the bladder (TURB) of high-grade T1 tumors and new techniques, such as hybrid knife TURB are coming up. The histopathological assessment of T1 tumors can be supplemented by a description of the exact penetration depth, so-called substaging and the invasion pattern. RESULTS: Intravesicle therapy with Bacillus Calmette-Guèrin (BCG) represents the gold standard and a pillar of bladder-preserving therapy and should be planned as maintenance therapy for at least 1 year. With the right risk constellation cystectomy is a safe and proven concept for high-grade bladder cancer, even without proof of muscle invasion.
Authors: Cyrill A Rentsch; Frédéric D Birkhäuser; Claire Biot; Joël R Gsponer; Aurélie Bisiaux; Christian Wetterauer; Micheline Lagranderie; Gilles Marchal; Mickael Orgeur; Christiane Bouchier; Alexander Bachmann; Molly A Ingersoll; Roland Brosch; Matthew L Albert; George N Thalmann Journal: Eur Urol Date: 2014-03-12 Impact factor: 20.096
Authors: Wolfgang Otto; Stefan Denzinger; Hans-Martin Fritsche; Maximilian Burger; Wolf F Wieland; Ferdinand Hofstädter; Arndt Hartmann; Simone Bertz Journal: BJU Int Date: 2010-08-12 Impact factor: 5.588
Authors: Baerin B Houghton; Venu Chalasani; Dickon Hayne; Peter Grimison; Christopher S B Brown; Manish I Patel; Ian D Davis; Martin R Stockler Journal: BJU Int Date: 2012-12-17 Impact factor: 5.588
Authors: Stefan Denzinger; Maximilian Burger; Hans-Martin Fritsche; Simone Bertz; Ferdinand Hofstädter; Wolf F Wieland; Arndt Hartmann; Wolfgang Otto Journal: Scand J Urol Nephrol Date: 2009
Authors: Per-Uno Malmström; Richard J Sylvester; David E Crawford; Martin Friedrich; Susanne Krege; Erkki Rintala; Eduardo Solsona; Savino M Di Stasi; J Alfred Witjes Journal: Eur Urol Date: 2009-04-24 Impact factor: 20.096
Authors: Jorg R Oddens; Richard J Sylvester; Maurizio A Brausi; Wim J Kirkels; Cees van de Beek; George van Andel; Theo M de Reijke; Stephen Prescott; J Alfred Witjes; Willem Oosterlinck Journal: Eur Urol Date: 2014-06-16 Impact factor: 20.096
Authors: Derya Tilki; Shahrokh F Shariat; Yair Lotan; Michael Rink; Pierre I Karakiewicz; Mark P Schoenberg; Seth P Lerner; Guru Sonpavde; Arthur I Sagalowsky; Amit Gupta Journal: BJU Int Date: 2012-11-26 Impact factor: 5.588