Literature DB >> 25800730

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.

Graham S Timmins1.   

Abstract

Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metabolism and host-pathogen phenotypic interactions.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  bacteria; breath test; diagnosis; metabolism; phenotype

Mesh：

Substances：

Year:  2015        PMID： 25800730      PMCID： PMC4458167          DOI： 10.1016/j.tim.2015.02.013

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  11 in total

1.  Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism.

Authors:  Wenwei Lin; Vanessa Mathys; Emily Lei Yin Ang; Vanessa Hui Qi Koh; Julia María Martínez Gómez; Michelle Lay Teng Ang; Siti Zarina Zainul Rahim; Mai Ping Tan; Kevin Pethe; Sylvie Alonso
Journal:  Infect Immun       Date:  2012-05-29       Impact factor: 3.441

Review 2.  Mechanisms of action of isoniazid.

Authors:  Graham S Timmins; Vojo Deretic
Journal:  Mol Microbiol       Date:  2006-10-27       Impact factor: 3.501

3.  Bringing RNA-seq closer to the clinic.

Authors:  Kendall Van Keuren-Jensen; Jonathan J Keats; David W Craig
Journal:  Nat Biotechnol       Date:  2014-09       Impact factor: 54.908

4.  Simple pyrazinamidase and urease tests for routine identification of mycobacteria.

Authors:  L G Wayne
Journal:  Am Rev Respir Dis       Date:  1974-01

5.  13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis.

Authors:  Mandeep S Jassal; Gueno G Nedeltchev; Jong-Hee Lee; Seong Won Choi; Viorel Atudorei; Zachary D Sharp; Vojo Deretic; Graham S Timmins; William R Bishai
Journal:  PLoS One       Date:  2010-08-27       Impact factor: 3.240

6.  Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction.

Authors:  D L Clemens; B Y Lee; M A Horwitz
Journal:  J Bacteriol       Date:  1995-10       Impact factor: 3.490

Review 7.  The mechanism of isoniazid killing: clarity through the scope of genetics.

Authors:  Catherine Vilchèze; William R Jacobs
Journal:  Annu Rev Microbiol       Date:  2007       Impact factor: 15.500

8.  Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.

Authors:  Ashwani Kumar; Jessy S Deshane; David K Crossman; Subhashini Bolisetty; Bo-Shiun Yan; Igor Kramnik; Anupam Agarwal; Adrie J C Steyn
Journal:  J Biol Chem       Date:  2008-04-09       Impact factor: 5.157

9.  In vitro and in vivo studies of a rapid and selective breath test for tuberculosis based upon mycobacterial CO dehydrogenase.

Authors:  Mamoudou Maiga; Seong Won Choi; Viorel Atudorei; Mariama C Maiga; Zachary D Sharp; William R Bishai; Graham S Timmins
Journal:  mBio       Date:  2014-04-15       Impact factor: 7.867

10.  Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test.

Authors:  Seong Won Choi; Mamoudou Maiga; Mariama C Maiga; Viorel Atudorei; Zachary D Sharp; William R Bishai; Graham S Timmins
Journal:  Nat Commun       Date:  2014-09-23       Impact factor: 14.919
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  2 in total

Review 1.  Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature.

Authors:  Graham S Timmins
Journal:  Expert Opin Ther Pat       Date:  2016-08-10       Impact factor: 6.674

2.  Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.

Authors:  Christina E M Krämer; Abhijeet Singh; Stefan Helfrich; Alexander Grünberger; Wolfgang Wiechert; Katharina Nöh; Dietrich Kohlheyer
Journal:  PLoS One       Date:  2015-10-29       Impact factor: 3.240
  2 in total

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