Literature DB >> 2580073

Evidence for the involvement of endogenous substance P in the motor effects of capsaicin on the rat urinary bladder.

C A Maggi, P Santicioli, A Meli.   

Abstract

[pro4,trp7,9,Leu11]SP-(4-11), a substance P (SP) antagonist, selectively antagonized contractions produced by either capsaicin or SP on the rat isolated urinary bladder. These experiments provide direct evidence indicating that the motor effects of capsaicin on rat urinary bladder are attributable, at least in part, to the release of endogenous SP.

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Year:  1985        PMID： 2580073     DOI： 10.1111/j.2042-7158.1985.tb05042.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  12 in total

1.  Capsaicin enhances the non-adrenergic twitch response of rat vas deferens.

Authors:  H Moritoki; T Iwamoto; J Kanaya; Y Ishida; K Ando; K Kitagawa
Journal:  Br J Pharmacol       Date:  1987-10       Impact factor: 8.739

2.  Species-related variations in the effects of capsaicin on urinary bladder functions: relation to bladder content of substance P-like immunoreactivity.

Authors:  C A Maggi; S Giuliani; P Santicioli; L Abelli; P Geppetti; V Somma; D Renzi; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

3.  Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract.

Authors:  C A Maggi; P Santicioli; L Abelli; M Parlani; M Capasso; B Conte; S Giuliani; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

4.  The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.

Authors:  C A Maggi; R Patacchini; P Santicioli; I T Lippe; S Giuliani; P Geppetti; E Del Bianco; S Selleri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-08       Impact factor: 3.000

5.  Modulation of neurotransmission in the guinea-pig vas deferens by capsaicin: involvement of calcitonin gene-related peptide and substance P.

Authors:  J L Ellis; G Burnstock
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

6.  Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

7.  Cystometric changes in the early phase of streptozotocin-induced diabetes in rats: evidence for sensory changes not correlated to diabetic neuropathy.

Authors:  P Santicioli; R Gamse; C A Maggi; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

Review 8.  Neuropeptides in pelvic afferent pathways.

Authors:  W C de Groat
Journal:  Experientia       Date:  1987-07-15

9.  Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons.

Authors:  C A Maggi; S Manzini; S Giuliani; P Santicioli; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-10       Impact factor: 3.000

10.  The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.

Authors:  Chikashi Saitoh; Chika Kitada; Wataru Uchida; Michael B Chancellor; William C de Groat; Naoki Yoshimura
Journal:  Eur J Pharmacol       Date:  2007-06-05       Impact factor: 4.432
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