Literature DB >> 2580054

Antibody response to type-common and type-unique epitopes of herpes simplex virus polypeptides.

D I Bernstein, Y J Bryson, M A Lovett.   

Abstract

Herpes simplex virus type 1 (HSV1) and type 2 (HSV2) polypeptides with type-common and type-unique epitopes were identified using cross-adsorbed hyperimmune rabbit sera and Western blotting techniques. Twelve HSV1 and fourteen HSV2 polypeptides with type-specific epitopes were identified. Cross-adsorbed human sera reacted to a subset of the type-specific epitopes defined by rabbit sera. Human sera with both HSV1- and HSV2-specific antibodies were identified by their reaction to HSV1-type-specific epitopes after adsorption with HSV2, and HSV2-type-specific epitopes after adsorption with HSV1. Mixing experiments demonstrated the sensitivity of this assay for detecting HSV2-type-specific antibody in the presence of HSV1 antibody. This technique has proven useful in the study of immune response to individual HSV polypeptides during human HSV infections, while the presence of these type-unique epitopes on HSV polypeptides allows for the detection of type-specific antibodies in human sera.

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Year:  1985        PMID： 2580054     DOI： 10.1002/jmv.1890150306

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  9 in total

1.  Highly sensitive enhanced chemiluminescence immunodetection method for herpes simplex virus type 2 Western immunoblot.

Authors:  J Dalessio; R Ashley
Journal:  J Clin Microbiol       Date:  1992-04       Impact factor: 5.948

2.  Evaluation of three glycoprotein G2-based enzyme immunoassays for detection of antibodies to herpes simplex virus type 2 in human sera.

Authors:  A M Eis-Hübinger; M Däumer; B Matz; K E Schneweis
Journal:  J Clin Microbiol       Date:  1999-05       Impact factor: 5.948

3.  Locations of herpes simplex virus type 2 glycoprotein B epitopes recognized by human serum immunoglobulin G antibodies.

Authors:  D E Goade; R Bell; T Yamada; G J Mertz; S Jenison
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

4.  Type specificity of complement-fixing antibody against herpes simplex virus type 2 AG-4 early antigen in patients with asymptomatic infection.

Authors:  C H Sherlock; R L Ashley; M L Shurtleff; K D Mack; L Corey
Journal:  J Clin Microbiol       Date:  1986-12       Impact factor: 5.948

5.  Production of herpes B virus recombinant glycoproteins and evaluation of their diagnostic potential.

Authors:  Ludmila Perelygina; Irina Patrusheva; Soumya Hombaiah; Holley Zurkuhlen; Martin J Wildes; Nikolai Patrushev; Julia Hilliard
Journal:  J Clin Microbiol       Date:  2005-02       Impact factor: 5.948

6.  Detection of immunoglobulin M antibodies to glycoprotein G-2 by western blot (immunoblot) for diagnosis of initial herpes simplex virus type 2 genital infections.

Authors:  D W Ho; P R Field; W L Irving; D R Packham; A L Cunningham
Journal:  J Clin Microbiol       Date:  1993-12       Impact factor: 5.948

7.  Herpes simplex virus 2 (HSV-2) infected cell proteins are among the most dominant antigens of a live-attenuated HSV-2 vaccine.

Authors:  Joshua J Geltz; Edward Gershburg; William P Halford
Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240

Review 8.  The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens.

Authors:  Aristo Vojdani; Elroy Vojdani; Avi Z Rosenberg; Yehuda Shoenfeld
Journal:  Pathophysiology       Date:  2022-06-03

9.  Optimized Expression, Purification of Herpes B Virus gD Protein in Escherichia coli, and Production of Its Monoclonal Antibodies.

Authors:  Zian Jin; Tao Sun; Xueshan Xia; Qiujiang Wei; Yuzhu Song; Qinqin Han; Qiang Chen; Juan Hu; Jinyang Zhang
Journal:  Jundishapur J Microbiol       Date:  2016-03-12       Impact factor: 0.747
  9 in total

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