| Literature DB >> 25800433 |
Roisin O'Keeffe1, Olivia Kenny2, Nigel P Brunton3, Mohammad B Hossain4, Dilip K Rai4, Peter W Jones5, Nora O'Brien6, Anita R Maguire7, Stuart G Collins8.
Abstract
In the present study, the synthesis of a range of novel 24-amino-25,26,27-trinorlanost-8-ene derivatives including 24-piperadino-trinorlanost-8-enes, 24-piperazino-trinorlanost-8-enes, 24-morpholino-trinorlanost-8-enes, and 24-diethylamino-trinorlanost-8-enes is reported and their cytotoxic and apoptotic potential evaluated in U937 cell lines. Excellent IC₅₀ results for piperidine and 1-(2-hydroxyethyl)piperazine derivatives have been observed (IC₅₀ values of 1.9 μM and 2.7 μM in U937 cells, respectively).Entities:
Keywords: Apoptosis; Lanostanes; Oxidative cleavage; Reductive amination; U937 cells
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Year: 2015 PMID： 25800433 DOI： 10.1016/j.bmc.2015.02.034
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641