Edward C Kuan1, Kevin A Peng1, Sunita Bhuta2, Miguel Fernando Palma Diaz2, Zuo-Feng Zhang3, Elliot Abemayor4, Maie A St John5. 1. Department of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA. 2. Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA; UCLA Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, CA. 3. Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA; Jonsson Comprehensive Cancer Center, UCLA Medical Center, Los Angeles, CA. 4. Department of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA; Jonsson Comprehensive Cancer Center, UCLA Medical Center, Los Angeles, CA; UCLA Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, CA. 5. Department of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA; Jonsson Comprehensive Cancer Center, UCLA Medical Center, Los Angeles, CA; UCLA Head and Neck Cancer Program, UCLA Medical Center, Los Angeles, CA. Electronic address: MStJohn@mednet.ucla.edu.
Abstract
PURPOSE: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma characterized by a highly aggressive clinical course. Though typically found in the larynx, oropharynx, and hypopharynx, we report a rare case of BSCC originating in the maxillary sinus in an otherwise healthy 32-year-old male. MATERIALS AND METHODS: Single case report of a patient with BSCC of the maxillary sinus and retrospective chart review of all cases of BSCC of the maxilla at a single academic institution between January 1, 1986 and December 31, 2013. The MEDLINE database was additionally queried for all case series or reports of BSCC arising in the maxilla, and pertinent clinical data were extracted. RESULTS: The clinical presentation, disease course, and management of a patient with BSCC of the maxilla are presented. In this recent case, the patient presented with persistent alveolar pain and a nonhealing tooth infection. Radiographic studies demonstrated a large necrotic mass in the left maxillary sinus that was biopsy-proven as BSCC. The patient underwent surgical resection followed by postoperative radiation without complications. CONCLUSIONS: BSCC of the maxilla is a rare oncologic entity that may progress to late disease stage without obvious clinical signs or symptoms. Optimal treatment involves complete surgical resection followed by postoperative.
PURPOSE: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma characterized by a highly aggressive clinical course. Though typically found in the larynx, oropharynx, and hypopharynx, we report a rare case of BSCC originating in the maxillary sinus in an otherwise healthy 32-year-old male. MATERIALS AND METHODS: Single case report of a patient with BSCC of the maxillary sinus and retrospective chart review of all cases of BSCC of the maxilla at a single academic institution between January 1, 1986 and December 31, 2013. The MEDLINE database was additionally queried for all case series or reports of BSCC arising in the maxilla, and pertinent clinical data were extracted. RESULTS: The clinical presentation, disease course, and management of a patient with BSCC of the maxilla are presented. In this recent case, the patient presented with persistent alveolar pain and a nonhealing tooth infection. Radiographic studies demonstrated a large necrotic mass in the left maxillary sinus that was biopsy-proven as BSCC. The patient underwent surgical resection followed by postoperative radiation without complications. CONCLUSIONS: BSCC of the maxilla is a rare oncologic entity that may progress to late disease stage without obvious clinical signs or symptoms. Optimal treatment involves complete surgical resection followed by postoperative.