Literature DB >> 2579841

Platelet hyperfunction in patients with chronic airways obstruction.

C Cordova, A Musca, F Violi, C Alessandri, A Perrone, F Balsano.   

Abstract

Platelet aggregation (PA) and plasma beta-thromboglobulin (beta TG) values were evaluated in 40 patients affected by chronic airway obstruction (CAO). PA and beta TG were significantly higher than those observed in normal subjects. Beta TG plasma levels were inversely correlated with PaO2, directly with PaCO2 and [H+]. Two h after a venesection of 300-400 ml, no change of beta TG and PA was seen in 10 healthy subjects, while a significant increase of beta TG and PA values was observed in 29 patients. The investigation suggests that in patients with CAO in vivo platelet activation is present.

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Year:  1985        PMID: 2579841

Source DB:  PubMed          Journal:  Eur J Respir Dis        ISSN: 0106-4339


  7 in total

1.  Inhibition by picotamide of thromboxane production in vitro and ex vivo.

Authors:  F Violi; A Ghiselli; L Iuliano; D Praticò; C Alessandri; F Balsano
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

2.  Platelet size in patients with chronic airflow obstruction with and without hypoxaemia.

Authors:  J A Wedzicha; F E Cotter; D W Empey
Journal:  Thorax       Date:  1988-01       Impact factor: 9.139

3.  Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia.

Authors:  J A Wedzicha; D Syndercombe-Court; K C Tan
Journal:  Thorax       Date:  1991-07       Impact factor: 9.139

Review 4.  Novel uses for anti-platelet agents as anti-inflammatory drugs.

Authors:  S C Pitchford
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739

Review 5.  Mechanisms of atherothrombosis in chronic obstructive pulmonary disease.

Authors:  Filippo Luca Fimognari; Simone Scarlata; Maria Elisabetta Conte; Raffaele Antonelli Incalzi
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2008

6.  Large-Scale Discovery of Disease-Disease and Disease-Gene Associations.

Authors:  Djordje Gligorijevic; Jelena Stojanovic; Nemanja Djuric; Vladan Radosavljevic; Mihajlo Grbovic; Rob J Kulathinal; Zoran Obradovic
Journal:  Sci Rep       Date:  2016-08-31       Impact factor: 4.379

7.  Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients.

Authors:  Mariana Muñoz-Esquerre; José Luis Ferreiro; Daniel Huertas; Ana Lucrecia Marcano; Marta López-Sánchez; Gerard Roura; Joan Antoni Gómez-Hospital; Jordi Dorca; Angel Cequier; Salud Santos
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2017-12-28
  7 in total

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