| Literature DB >> 2579829 |
K E Barrett, T L Tashof, D D Metcalfe.
Abstract
The effect of sulphasalazine on two mast cell populations and human peripheral leukocytes is reported. Sulphasalazine inhibited histamine release from mouse and rat mast cells, but it caused a potentiation of secretion in human peripheral leukocytes. The drug alone did not induce histamine release when administered without an anaphylactic stimulus. The results are discussed in terms of a possible mode of action of sulphasalazine in the treatment of inflammatory bowel disease.Entities:
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Year: 1985 PMID： 2579829 DOI： 10.1016/0014-2999(85)90071-8
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432