| Literature DB >> 25797920 |
Aby Cheruvathoor Poulose1, Srivani Veeranarayanan1, M Sheikh Mohamed1, Yutaka Nagaoka1, Rebeca Romero Aburto2, Trevor Mitcham3, Pulickel M Ajayan2, Richard R Bouchard3, Yasushi Sakamoto4, Yasuhiko Yoshida1, Toru Maekawa1, D Sakthi Kumar1.
Abstract
A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.Entities:
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Year: 2015 PMID： 25797920 PMCID： PMC4528641 DOI： 10.1039/c4nr07139e
Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790