Literature DB >> 2579706

Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.

Y Kuraishi, N Hirota, Y Sato, Y Hino, M Satoh, H Takagi.   

Abstract

Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.

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Year:  1985        PMID： 2579706     DOI： 10.1016/0006-8993(85)90326-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  30 in total

1.  Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists.

Authors:  K J Powell; W Ma; M Sutak; H Doods; R Quirion; K Jhamandas
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

2.  Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole.

Authors:  Paul D Marasco; Pamela R Tsuruda; Diana M Bautista; David Julius; Kenneth C Catania
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-02       Impact factor: 11.205

3.  Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn.

Authors:  Beth K Rycroft; Kristina S Vikman; MacDonald J Christie
Journal:  J Physiol       Date:  2007-02-15       Impact factor: 5.182

4.  Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.

Authors:  C Abbadie; J Trafton; H Liu; P W Mantyh; A I Basbaum
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

5.  Reactions of neurons of the somatosensory cortex of the rabbit to nociceptive stimuli of varying genesis.

Authors: 
Journal:  Neurosci Behav Physiol       Date:  1991 Mar-Apr

6.  Neurons in the dorsal column white matter of the spinal cord: complex neuropil in an unexpected location.

Authors:  C Abbadie; K Skinner; I Mitrovic; A I Basbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

7.  Ultrastructural studies on calcitonin gene-related peptide-, tachykinins- and somatostatin-immunoreactive neurones in rat dorsal root ganglia: evidence for the colocalization of different peptides in single secretory granules.

Authors:  A Merighi; J M Polak; S J Gibson; S Gulbenkian; K L Valentino; S M Peirone
Journal:  Cell Tissue Res       Date:  1988-10       Impact factor: 5.249

8.  Somatostatin inhibits excitatory transmission at rat hippocampal synapses via presynaptic receptors.

Authors:  S Boehm; H Betz
Journal:  J Neurosci       Date:  1997-06-01       Impact factor: 6.167

9.  Involvement of spinal somatostatin receptor SST(2A) in inflammation-induced thermal hyperalgesia: ultrastructural and behavioral studies in rats.

Authors:  Jun Zhao; Jiang-Yuan Hu; Yu-Qiu Zhang; Zhi-Qi Zhao
Journal:  Neurochem Res       Date:  2008-05-02       Impact factor: 3.996

10.  Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.

Authors:  Sung Jun Jung; Su-Hyun Jo; Sanghyuck Lee; Eunhui Oh; Min-Seok Kim; Woo Dong Nam; Seog Bae Oh
Journal:  Korean J Physiol Pharmacol       Date:  2008-10-31       Impact factor: 2.016
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